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Sci Rep

Title:		Odours of Plasmodium falciparum-infected participants influence mosquito-host interactions
Author(s):		de Boer JG; Robinson A; Powers SJ; Burgers S; Caulfield JC; Birkett MA; Smallegange RC; van Genderen PJJ; Bousema T; Sauerwein RW; Pickett JA; Takken W; Logan JG;
Address:		"Laboratory of Entomology, Wageningen University, Droevendaalsesteeg 1, 6708, PB, Wageningen, The Netherlands. j.deboer@nioo.knaw.nl. Netherlands Institute of Ecology, Droevendaalsesteeg 10, 6708, PB, Wageningen, The Netherlands. j.deboer@nioo.knaw.nl. London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom. Computational and Systems Biology Department, Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, United Kingdom. Biometris, Wageningen University, Droevendaalsesteeg 1, 6708, PB, Wageningen, The Netherlands. Biological Chemistry and Crop Protection Department, Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, United Kingdom. Laboratory of Entomology, Wageningen University, Droevendaalsesteeg 1, 6708, PB, Wageningen, The Netherlands. Institute for Tropical Diseases, Harbour Hospital Rotterdam, Haringvliet 72, 3011, TG, Rotterdam, The Netherlands. Medical Microbiology, Radboud University Medical Centre, Geert Grooteplein 26-28, 6525, GA, Nijmegen, The Netherlands"
Journal Title:		Sci Rep
Year:		2017
Volume:		20170824
Issue:		1
Page Number:		9283 -
DOI:		10.1038/s41598-017-08978-9
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"Malaria parasites are thought to influence mosquito attraction to human hosts, a phenomenon that may enhance parasite transmission. This is likely mediated by alterations in host odour because of its importance in mosquito host-searching behaviour. Here, we report that the human skin odour profile is affected by malaria infection. We compared the chemical composition and attractiveness to Anopheles coluzzii mosquitoes of skin odours from participants that were infected by Controlled Human Malaria Infection with Plasmodium falciparum. Skin odour composition differed between parasitologically negative and positive samples, with positive samples collected on average two days after parasites emerged from the liver into the blood, being associated with low densities of asexual parasites and the absence of gametocytes. We found a significant reduction in mosquito attraction to skin odour during infection for one experiment, but not in a second experiment, possibly due to differences in parasite strain. However, it does raise the possibility that infection can affect mosquito behaviour. Indeed, several volatile compounds were identified that can influence mosquito behaviour, including 2- and 3-methylbutanal, 3-hydroxy-2-butanone, and 6-methyl-5-hepten-2-one. To better understand the impact of our findings on Plasmodium transmission, controlled studies are needed in participants with gametocytes and higher parasite densities"
Keywords:		"Animals Behavior, Animal *Culicidae Gas Chromatography-Mass Spectrometry *Host-Parasite Interactions Humans Malaria, Falciparum/*metabolism/*parasitology/transmission Metabolomics/methods *Odorants *Plasmodium falciparum Skin/metabolism Volatile Organic C;"
Notes:		"Medlinede Boer, Jetske G Robinson, Ailie Powers, Stephen J Burgers, Saskia L G E Caulfield, John C Birkett, Michael A Smallegange, Renate C van Genderen, Perry J J Bousema, Teun Sauerwein, Robert W Pickett, John A Takken, Willem Logan, James G eng Biotechnology and Biological Sciences Research Council/United Kingdom Research Support, Non-U.S. Gov't England 2017/08/26 Sci Rep. 2017 Aug 24; 7(1):9283. doi: 10.1038/s41598-017-08978-9"