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Biomed Rep

Title:		Urinary volatile organic compounds as potential biomarkers for renal cell carcinoma
Author(s):		Wang D; Wang C; Pi X; Guo L; Wang Y; Li M; Feng Y; Lin Z; Hou W; Li E;
Address:		"Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China"
Journal Title:		Biomed Rep
Year:		2016
Volume:		20160520
Issue:		1
Page Number:		68 - 72
DOI:		10.3892/br.2016.686
ISSN/ISBN:		2049-9434 (Print) 2049-9442 (Electronic) 2049-9434 (Linking)
Abstract:		"Currently, there is no adequate, sensitive, reproducible, specific and noninvasive biomarker that can reliably be used to detect renal cell carcinoma (RCC). Previous studies have elucidated the urinary non-volatile metabolic profile of RCC. However, whether urinary volatile organic compound (VOC) profiles are able to identify RCC remains to be elucidated. In the present study, urine was collected from 22 patients with RCC and 25 healthy subjects. Principal component analysis and orthogonal partial least square discriminant analysis were used to compare the data of patients and healthy subjects, and preoperative and postoperative patients undergoing radical nephrectomy. In total, 11 VOC biomarkers were elevated in the RCC patients compared to the healthy subjects, which were phenol; decanal; 1,6-dioxacyclododecane-7,12-dione; 1-bromo-1-(3-methyl-1-pentenylidene)-2,2,3,3-tetramethyl-cyclopropane; nonanal; 3-ethyl-3-methylheptane; isolongifolene-5-ol; 2,5-cyclohexadiene-1,4-dione, 2,6-bis(1,1-dimethylethyl); tetradecane; aniline; and 2,6,10,14-tetramethyl-pentadecane. Three biomarkers were decreased in RCC patients: styrene, 4-heptanone and dimethylsilanediol. In preoperative patients, 2-ethyl-1-hexanol and cyclohexanone were elevated, while 6-t-butyl-2,2,9,9-tetramethyl-3,5-decadien-7-yne were decreased when compared to postoperative patients. Compared with the healthy subjects, RCC has a unique VOC profile, suggesting that VOC profiles may be a useful diagnostic assay for RCC"
Keywords:		biomarker diagnosis renal cell carcinoma urine volatile organic compound;
Notes:		"PubMed-not-MEDLINEWang, Dongchun Wang, Changsong Pi, Xin Guo, Lei Wang, Yue Li, Mingjuan Feng, Yue Lin, Ziwei Hou, Wei Li, Enyou eng England 2016/06/28 Biomed Rep. 2016 Jul; 5(1):68-72. doi: 10.3892/br.2016.686. Epub 2016 May 20"