| Title: | Real time analysis of breath volatiles using SIFT-MS in cigarette smoking |
| Author(s): | Senthilmohan ST; McEwan MJ; Wilson PF; Milligan DB; Freeman CG; |
| Address: | "Department of Chemical and Process Engineering, University of Canterbury, Christchurch, New Zealand. senti@cape.canterbury.ac.nz" |
| DOI: | 10.1179/135100001101536166 |
| ISSN/ISBN: | 1351-0002 (Print) 1351-0002 (Linking) |
| Abstract: | "The selected ion flow tube mass spectrometry (SIFT-MS) technique enables real time analysis of trace volatiles at ppb levels without preconcentration steps or chemical derivatization. Most previous studies of trace compounds on the breath were analyzed using gas chromatography where enhanced detection sensitivity was achieved by concentrating the breath using cryogenic or adsorption trapping techniques. In this paper, we have examined volatile organic substances, isoprene, acetone, ammonia and ethanol in breath before and after smoking a cigarette. It is interesting that isoprene levels increased in all the subjects after smoking one cigarette with a mean increase of 70%. The mean increase for acetone was found to be 22%. In contrast to isoprene, a decreasing ethanol level was observed in all the subjects except one with the negative mean decrease of 28%. Further SIFT-MS studies also have high-lighted some organic substances produced even by unburned cigarettes, US and New Zealand products. Certain US brands have shown much higher levels of volatile species than cigarettes produced in New Zealand" |
| Keywords: | Acetone/*analysis Adult Ammonia/*analysis Breath Tests/*methods Butadienes/*analysis Computer Systems Ethanol/*analysis Female *Hemiterpenes Humans Male Mass Spectrometry/*methods Methanol/analysis Middle Aged New Zealand *Pentanes Propylene Glycol/analys; |
| Notes: | "MedlineSenthilmohan, S T McEwan, M J Wilson, P F Milligan, D B Freeman, C G eng Research Support, Non-U.S. Gov't England 2001/08/29 Redox Rep. 2001; 6(3):185-7. doi: 10.1179/135100001101536166" |
