| Title: | Utility of SIFT-MS to evaluate volatile organic compounds in nephropathic patients' breath |
| Author(s): | Romani A; Marrone G; Celotto R; Campo M; Vita C; Chiaramonte C; Carretta A; Di Daniele N; Noce A; |
| Address: | "PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement, Technology and Analysis), DiSIA, University of Florence, 50019, Sesto Fiorentino, Florence, Italy. UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133, Rome, Italy. Department of Cardiovascular Disease, Tor Vergata University of Rome, 00133, Rome, Italy. QuMAP-PIN S.c.r.l.-Polo Universitario 'Citta di Prato' Servizi Didattici e Scientifici per L'Universita di Firenze, Piazza Giovanni Ciardi, 25, 59100, Prato, Italy. Department of Statistics, University of Rome Tor Vergata, 00133, Rome, Italy. SRA Instruments SpA, Cernusco Sul Naviglio, Milan, Italy. UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133, Rome, Italy. didaniele@med.uniroma2.it. UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133, Rome, Italy. annalisa.noce@uniroma2.it" |
| DOI: | 10.1038/s41598-022-14152-7 |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Several studies highlighted a correlation between exhaled air volatile organic compounds (VOCs) and some pathological conditions, such as chronic kidney disease (CKD), chronic liver disease, etc. In fact, in literature has been reported that CKD is characterized by an increased concentration of ammonia, trimethylamine (TMA) and isoprene compared to healthy subjects. Currently, there is not a validate and standardized method to detect VOCs. For this purpose, we examined the utility of selected ion flow tube-mass spectrometry (SIFT-MS) to measure VOCs in CKD patients and we evaluated the possible correlation between VOCs and the presence of CKD and its stage. We enrolled 68 CKD patients under conservative therapy and 54 healthy subjects. The analysis of the VOCs of the exhaled air of the enrolled subjects was performed by SIFT-MS. Among all the VOCs analyzed, the most relevant results by ROC curves were observed for TMA, acetone, ammonia and dimethyl sulfide. We found that a breath TMA concentration superior to 26 ppbv characterizes a 6.11 times greater risk of CKD, compared to subjects with lower levels. Moreover, we detected an increased concentration of acetone and ammonia in CKD patients compared to healthy subjects. We highlight the potential utility of SIFT-MS in CKD clinical management.Clinical trial registry: R.S. 15.19 of 6 February 2019" |
| Keywords: | "Acetone/analysis Ammonia Breath Tests/methods Humans *Renal Insufficiency, Chronic/diagnosis *Volatile Organic Compounds/analysis;" |
| Notes: | "MedlineRomani, Annalisa Marrone, Giulia Celotto, Roberto Campo, Margherita Vita, Chiara Chiaramonte, Carlo Carretta, Andrea Di Daniele, Nicola Noce, Annalisa eng England 2022/06/22 Sci Rep. 2022 Jun 21; 12(1):10413. doi: 10.1038/s41598-022-14152-7" |
