« Previous AbstractRoot Colonization by Fungal Entomopathogen Systemically Primes Belowground Plant Defense against Cabbage Root Fly    Next AbstractSignal transduction by MAP kinase cascades in budding yeast »

Science

Title:		Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK
Author(s):		Posas F; Saito H;
Address:		"Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115, USA"
Journal Title:		Science
Year:		1997
Volume:		276
Issue:		5319
Page Number:		1702 - 1705
DOI:		10.1126/science.276.5319.1702
ISSN/ISBN:		0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"Exposure of the yeast Saccharomyces cerevisiae to high extracellular osmolarity induces the Sln1p-Ypd1p-Ssk1p two-component osmosensor to activate a mitogen-activated protein (MAP) kinase cascade composed of the Ssk2p and Ssk22p MAP kinase kinase kinases (MAPKKKs), the Pbs2p MAPKK, and the Hog1p MAPK. A second osmosensor, Sho1p, also activated Pbs2p and Hog1p, but did so through the Ste11p MAPKKK. Although Ste11p also participates in the mating pheromone-responsive MAPK cascade, there was no detectable cross talk between these two pathways. The MAPKK Pbs2p bound to the Sho1p osmosensor, the MAPKKK Ste11p, and the MAPK Hog1p. Thus, Pbs2p may serve as a scaffold protein"
Keywords:		"Calcium-Calmodulin-Dependent Protein Kinases/*metabolism Enzyme Activation Genes, Fungal Genetic Complementation Test MAP Kinase Kinase Kinases Mating Factor *Mitogen-Activated Protein Kinase Kinases *Mitogen-Activated Protein Kinases Mutation Osmolar Con;"
Notes:		"MedlinePosas, F Saito, H eng GM50909/GM/NIGMS NIH HHS/ GM53415/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1997/06/13 Science. 1997 Jun 13; 276(5319):1702-5. doi: 10.1126/science.276.5319.1702"