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Arch Toxicol

Title:		"Sensory irritation mechanisms investigated from model compounds: trifluoroethanol, hexafluoroisopropanol and methyl hexafluoroisopropyl ether"
Author(s):		Nielsen GD; Abraham MH; Hansen LF; Hammer M; Cooksey CJ; Andonian-Haftvan J; Alarie Y;
Address:		"National Institute of Occupational Health, Copenhagen, Denmark"
Journal Title:		Arch Toxicol
Year:		1996
Volume:		70
Issue:		6
Page Number:		319 - 328
DOI:		10.1007/s002040050281
ISSN/ISBN:		0340-5761 (Print) 0340-5761 (Linking)
Abstract:		"Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroethanol, hexafluoroisopropanol and methyl hexafluoroisopropyl ether, were selected for study. The potency of each chemical is obtained from the concentration necessary to reduce respiratory rate in mice by 50% (RD50). The RD50 values obtained were: methyl hexafluoroisopropyl ether (> or = 160,000 ppm), trifluoroethanol (11,400-23,300 ppm), and hexafluoroisopropanol (165 ppm). QSAR showed that trifluoroethanol and methyl hexafluoroisopropyl ether behaved as predicted as nonreactive sensory irritants, whereas hexafluoroisopropanol was much more potent than predicted. The higher than predicted potency of hexafluoroisopropanol could be due to a coupled reaction, involving both strong hydrogen bonding and weak Bronsted acidity. A concerted reaction could thus be more efficient in activation of the receptor. Hydrogen bonding properties and concerted reactions may be important in the activation of the sensory irritant receptor by nonreactive volatile organic chemicals"
Keywords:		"1-Propanol/toxicity Animals Dose-Response Relationship, Drug Irritants/*toxicity Male Methyl Ethers/*toxicity Mice Mice, Inbred Strains Models, Chemical *Propanols Respiration/drug effects Trifluoroethanol/*toxicity;"
Notes:		"MedlineNielsen, G D Abraham, M H Hansen, L F Hammer, M Cooksey, C J Andonian-Haftvan, J Alarie, Y eng Germany 1996/01/01 Arch Toxicol. 1996; 70(6):319-28. doi: 10.1007/s002040050281"