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Talanta

Title:		Thermal desorption modulation for comprehensive two-dimensional gas chromatography using a simple and inexpensive segmented-loop fluidic interface
Author(s):		Mucedola V; Vieira LCS; Pierone D; Gobbi AL; Poppi RJ; Hantao LW;
Address:		"Laboratorio Nacional de Nanotecnologia, Centro Nacional de Pesquisa em Energia e Materiais, Campinas, SP 13083-100, Brazil; Instituto de Quimica, Universidade Estadual de Campinas, Campinas, SP 13083-970, Brazil. Laboratorio Nacional de Nanotecnologia, Centro Nacional de Pesquisa em Energia e Materiais, Campinas, SP 13083-100, Brazil. Nova Analitica Importacao Exportacao LTDA, Sao Paulo, SP 04131-000, Brazil. Laboratorio Nacional de Nanotecnologia, Centro Nacional de Pesquisa em Energia e Materiais, Campinas, SP 13083-100, Brazil; Instituto de Quimica, Universidade Estadual de Campinas, Campinas, SP 13083-970, Brazil. Electronic address: leandro.hantao@lnnano.cnpem.br"
Journal Title:		Talanta
Year:		2017
Volume:		20161207
Issue:
Page Number:		470 - 476
DOI:		10.1016/j.talanta.2016.12.005
ISSN/ISBN:		1873-3573 (Electronic) 0039-9140 (Linking)
Abstract:		"In this study, we introduce a modulation strategy for comprehensive two-dimensional gas chromatography (GCxGC) by using a simple and consumable-free modulator. This 'Do-It-Yourself' interface comprised a 1.0mx0.25mm segment of MTX-5 metallic column and a low-cost DC power supply. Thermal desorption modulation (TDM) was attained using a dual-stage heater-based modulator in a novel segmented-loop configuration. TDM was achieved by alternating analyte trapping and thermal desorption. Former process relied on analyte partition to sorbent phase, while latter explored direct resistive heating. Introduction of an intermediate delay segment between the two stages mitigated analyte breakthrough, improving peak symmetry and chromatographic efficiency. This feature was critical to acquire reliable GCxGC modulation using such simple heater-based device. The effects of important modulation variables on 2D separations were investigated, including TDM stage length, dimension of delay loop, and outlet pressure. Significant advances and limitations of proposed TDM strategy were carefully determined. Proposed GCxGC prototype by using an in-oven TDM modulator was successfully applied to a series of challenging matrices, including petroleum distillates, biodiesel, and essential oil. This open-hardware, cost-effective modulator was easy to install and operate, as it circumvented the need for sophisticated components (e.g. moving parts and cooling systems). Therefore, our modulator is a compelling alternative to existing GCxGC solutions to operate in resource-limited laboratories"
Keywords:		Chemical education Mass spectrometry Multidimensional gas chromatography Petroleum Poly(dimethylsiloxane) Volatile organic compound;
Notes:		"PubMed-not-MEDLINEMucedola, Vanessa Vieira, Luis C S Pierone, Danilo Gobbi, Angelo L Poppi, Ronei J Hantao, Leandro W eng Netherlands 2017/01/22 Talanta. 2017 Mar 1; 164:470-476. doi: 10.1016/j.talanta.2016.12.005. Epub 2016 Dec 7"