Bedoukian   RussellIPM   RussellIPM   Piezoelectric Micro-Sprayer


Home
Animal Taxa
Plant Taxa
Semiochemicals
Floral Compounds
Semiochemical Detail
Semiochemicals & Taxa
Synthesis
Control
Invasive spp.
References

Abstract

Guide

Alphascents
Pherobio
InsectScience
E-Econex
Counterpart-Semiochemicals
Print
Email to a Friend
Kindly Donate for The Pherobase

« Previous AbstractSynergistic Effect of Surface Acidity and PtO(x) Catalyst on the Sensitivity of Nanosized Metal-Oxide Semiconductors to Benzene    Next AbstractOptimization of thin film-microextraction (TF-SPME) method in order to determine musts volatile compounds »

Front Neurosci


Title:Olfactory Signatures in the Food Finding Test in Mice With Normal and Alzheimer's Disease-Pathological Aging With Special Concerns on the Effects of Social Isolation
Author(s):Marin-Pardo D; Gimenez-Llort L;
Address:"Institut de Neurociencies, Universitat Autonoma de Barcelona, Barcelona, Spain. Department of Psychiatry and Forensic Medicine, School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain"
Journal Title:Front Neurosci
Year:2021
Volume:20211005
Issue:
Page Number:733984 -
DOI: 10.3389/fnins.2021.733984
ISSN/ISBN:1662-4548 (Print) 1662-453X (Electronic) 1662-453X (Linking)
Abstract:"The temporal course and the severity of the involution of sensory systems through aging can be critical since they ensure the ability to perceive and recognize the world. In older people, sensory impairments significantly increase their risk of biological, psychological, and social impoverishment. Besides this, olfactory loss is considered an early biomarker in Alzheimer's disease (AD) neurodegenerative process. Here we studied olfactory ethograms in middle-aged male and female gold-standard C57BL/6 mice and 3xTg-AD mice, a genetic model of AD that presents cognitive dysfunction and a conspicuous neuropsychiatric-like phenotype. A paradigm involving 1-day food deprivation was used to investigate the ethological patterns shown in the olfactory inspection of a new cage and the sniffing, finding, and eating of hidden food pellets. The sniffing-find-eat temporal patterns were independent of the loss of weight and unveiled (fast) olfactory signatures in Alzheimer's disease, differing from those (slow progressive) in normal aging. Male 3xTg-AD mice exhibited an early signature than female mice, opposite to animals with normal aging. The sequence of actions was correlated in male and female 3xTg-AD mice in contrast to control mice. Social isolation, naturally occurring in male 3xTg-AD due to the death of cage mates, emphasized their olfactory patterns and disrupted the behavioral correlates. The paradigm provided distinct contextual, sex, and genotype olfactory ethogram signatures useful to investigate olfactory function in normal and AD-pathological aging. Isolation had an impact on enhancing the changes in the olfactory signature here described, for the first time, in the 3xTg-AD model of Alzheimer's disease"
Keywords:3xTg-AD mice Alzheimer's disease aging behavioral neuroscience ethogram methods neuroethology smell loss;
Notes:"PubMed-not-MEDLINEMarin-Pardo, Daniela Gimenez-Llort, Lydia eng Switzerland 2021/10/23 Front Neurosci. 2021 Oct 5; 15:733984. doi: 10.3389/fnins.2021.733984. eCollection 2021"

 
Back to top
 
Citation: El-Sayed AM 2024. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
© 2003-2024 The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.
Page created on 25-12-2024