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Peptides


Title:"The pheromone biosynthesis activating neuropeptide (PBAN) receptor of Heliothis virescens: identification, functional expression, and structure-activity relationships of ligand analogs"
Author(s):Kim YJ; Nachman RJ; Aimanova K; Gill S; Adams ME;
Address:"Department of Entomology, 2103 Biological Sciences Building, University of California, Riverside, CA 92521, United States"
Journal Title:Peptides
Year:2008
Volume:20071205
Issue:2
Page Number:268 - 275
DOI: 10.1016/j.peptides.2007.12.001
ISSN/ISBN:0196-9781 (Print) 1873-5169 (Electronic) 0196-9781 (Linking)
Abstract:"Pheromone biosynthesis activating neuropeptide (PBAN) promotes synthesis and release of sex pheromones in moths. We have identified and functionally expressed a PBAN receptor from Heliothis virescens (HevPBANR) and elucidated structure-activity relationships of PBAN analogs. Screening of a larval CNS cDNA library revealed three putative receptor subtypes and nucleotide sequence comparisons suggest that they are produced through alternative splicing at the 3'-end. RT-PCR amplified preferentially HevPBANR-C from female pheromone glands. CHO cells expressing HevPBANR-C are highly sensitive to PBAN and related analogs, especially those sharing the C-terminal pentapeptide core, FXPRLamide (X=T, S or V). Alanine replacements in the C-terminal hexapeptide (YFTPRLamide) revealed the relative importance of each residue in the active core as follows: R5>L6>F2>>P4>T3>>Y1. This study provides a framework for the rational design of PBANR-specific agonists and/or antagonists that could be exploited for disruption of reproductive function in agriculturally important insect pests"
Keywords:"Aequorin/genetics Amino Acid Sequence Animals CHO Cells Calcium Signaling/drug effects Central Nervous System/metabolism Cricetinae Cricetulus DNA, Complementary/chemistry/genetics Female GTP-Binding Protein alpha Subunits, Gq-G11/genetics Heterotrimeric;"
Notes:"MedlineKim, Young-Joon Nachman, Ronald J Aimanova, Karlygash Gill, Sarjeet Adams, Michael E eng R01 GM067310/GM/NIGMS NIH HHS/ GM 067310/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural 2008/02/05 Peptides. 2008 Feb; 29(2):268-75. doi: 10.1016/j.peptides.2007.12.001. Epub 2007 Dec 5"

 
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Citation: El-Sayed AM 2024. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
© 2003-2024 The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.
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