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Science

Title:		Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans
Author(s):		Kim K; Sato K; Shibuya M; Zeiger DM; Butcher RA; Ragains JR; Clardy J; Touhara K; Sengupta P;
Address:		"Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA"
Journal Title:		Science
Year:		2009
Volume:		20091001
Issue:		5955
Page Number:		994 - 998
DOI:		10.1126/science.1176331
ISSN/ISBN:		1095-9203 (Electronic) 0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"Intraspecific chemical communication is mediated by signals called pheromones. Caenorhabditis elegans secretes a mixture of small molecules (collectively termed dauer pheromone) that regulates entry into the alternate dauer larval stage and also modulates adult behavior via as yet unknown receptors. Here, we identify two heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) that mediate dauer formation in response to a subset of dauer pheromone components. The SRBC-64 and SRBC-66 GPCRs are members of the large Caenorhabditis-specific SRBC subfamily and are expressed in the ASK chemosensory neurons, which are required for pheromone-induced dauer formation. Expression of both, but not each receptor alone, confers pheromone-mediated effects on heterologous cells. Identification of dauer pheromone receptors will allow a better understanding of the signaling cascades that transduce the context-dependent effects of ecologically important chemical signals"
Keywords:		Animals Caenorhabditis elegans/genetics/*growth & development/*physiology Caenorhabditis elegans Proteins/genetics/physiology Calcium/metabolism Cell Line Chemoreceptor Cells/metabolism Cyclic AMP/metabolism Cyclic GMP/metabolism GTP-Binding Protein alpha;
Notes:		"MedlineKim, Kyuhyung Sato, Koji Shibuya, Mayumi Zeiger, Danna M Butcher, Rebecca A Ragains, Justin R Clardy, Jon Touhara, Kazushige Sengupta, Piali eng R01 CA24487/CA/NCI NIH HHS/ R01 GM56223/GM/NIGMS NIH HHS/ R01 CA024487/CA/NCI NIH HHS/ P30 NS045713/NS/NINDS NIH HHS/ R01 GM056223/GM/NIGMS NIH HHS/ F32 GM077943/GM/NIGMS NIH HHS/ P30 NS45713/NS/NINDS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2009/10/03 Science. 2009 Nov 13; 326(5955):994-8. doi: 10.1126/science.1176331. Epub 2009 Oct 1"