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ANZ J Surg

Title:		Potential role of volatile organic compound breath testing in the Australasian colorectal cancer pathway
Author(s):		Gower H; Danielson K; Dennett APE; Deere J;
Address:		"Dept Surgery and Anaesthesia, University of Otago, Wellington, New Zealand. Callaghan Innovation, Wellington, New Zealand"
Journal Title:		ANZ J Surg
Year:		2023
Volume:		20230111
Issue:		5
Page Number:		1159 - 1161
DOI:		10.1111/ans.18195
ISSN/ISBN:		1445-2197 (Electronic) 1445-1433 (Linking)
Abstract:		"With colonoscopy resources under pressure and inequitable participation rates in our screening programmes, there is an urgent need to consider trialling new testing technology for the detection of colorectal cancer (CRC) in Australasia. Research has shown that volatile organic compounds (VOCs) emitted from the human body can act as biomarkers for CRC, indicating high sensitivity and specificity for early and late-stage CRC and for adenomatous polyps. Breath-based VOC testing shows promise due to acceptability and ease of sampling via simple hand-held devices. Analysis can occur via mass spectrometry, or via 'e-nose' or sensor techniques. This review summarizes the current state of knowledge in using VOC-based testing for CRC. Adoption of this technique has the potential to improve CRC survival, reduce incidence and reduce colonoscopy burden in Australasia, and positively impact on ethnic disparities in cancer outcomes. Future multicentre trials should be conducted using standardized processes and protocols. This will ensure accuracy and reproducibility under different environmental and physiological conditions, and for different ethnic groups. Studies should be explicitly targeted to various points along the CRC patient pathway"
Keywords:		Humans Reproducibility of Results *Volatile Organic Compounds Australasia *Colorectal Neoplasms/diagnosis Breath Tests breath test cancer diagnosis colorectal cancer volatile organic compound volatolomic;
Notes:		"MedlineGower, Helen Danielson, Kirsty Dennett, A P Elizabeth Deere, Joseph eng University of Otago Wellington PhD scholarship/ Review Australia 2023/01/12 ANZ J Surg. 2023 May; 93(5):1159-1161. doi: 10.1111/ans.18195. Epub 2023 Jan 11"