| Title: | "Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability" |
| Address: | "Department of Molecular Pharmacology, CCSR, 269 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305-5174, USA. james.ferrell@stanford.edu" |
| DOI: | 10.1016/s0955-0674(02)00314-9 |
| ISSN/ISBN: | 0955-0674 (Print) 0955-0674 (Linking) |
| Abstract: | "Cell signaling systems that contain positive-feedback loops or double-negative feedback loops can, in principle, convert graded inputs into switch-like, irreversible responses. Systems of this sort are termed 'bistable'. Recently, several groups have engineered artificial bistable systems into Escherichia coli and Saccharomyces cerevisiae, and have shown that the systems exhibit interesting and potentially useful properties. In addition, two naturally occurring signaling systems, the p42 mitogen-activated protein kinase and c-Jun amino-terminal kinase pathways in Xenopus oocytes, have been shown to exhibit bistable responses. Here we review the basic properties of bistable circuits, the requirements for construction of a satisfactory bistable switch, and the recent progress towards constructing and analysing bistable signaling systems" |
| Keywords: | "Animals CDC2 Protein Kinase/*metabolism Enzyme Activation Enzyme Stability Escherichia coli Feedback, Physiological/*physiology Female JNK Mitogen-Activated Protein Kinases Mating Factor Mitogen-Activated Protein Kinase 1/*metabolism Mitogen-Activated Pro;" |
| Notes: | "MedlineFerrell, James E Jr eng Research Support, U.S. Gov't, P.H.S. Review England 2002/03/14 Curr Opin Cell Biol. 2002 Apr; 14(2):140-8. doi: 10.1016/s0955-0674(02)00314-9" |
