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Sci Rep

Title:		A single identified glomerulus in the zebrafish olfactory bulb carries the high-affinity response to death-associated odor cadaverine
Author(s):		Dieris M; Ahuja G; Krishna V; Korsching SI;
Address:		"Institute of Genetics, Biocenter, University at Cologne, Cologne, Germany"
Journal Title:		Sci Rep
Year:		2017
Volume:		20170119
Issue:
Page Number:		40892 -
DOI:		10.1038/srep40892
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"The death-associated odor cadaverine, generated by bacteria-mediated decarboxylation of lysine, has been described as the principal activator of a particular olfactory receptor in zebrafish, TAAR13c. Low concentrations of cadaverine activated mainly TAAR13c-expressing olfactory sensory neurons, suggesting TAAR13c as an important element of the neuronal processing pathway linking cadaverine stimulation to a strongly aversive innate behavioral response. Here, we characterized the initial steps of this neuronal pathway. First we identified TAAR13c-expressing cells as ciliated neurons, equivalent to the situation for mammalian taar genes, which shows a high degree of conservation despite the large evolutionary distance between teleost fishes and mammals. Next we identified the target area of cadaverine-responsive OSNs in the olfactory bulb. We report that cadaverine dose-dependently activates a group of dorsolateral glomeruli, at the lowest concentration down to a single invariant glomerulus, situated at the medial border of the dorsolateral cluster. This is the first demonstration of a single stereotyped target glomerulus in the fish olfactory system for a non-pheromone odor. A mix of different amines activates many glomeruli within the same dorsolateral cluster, suggesting this area to function as a general amine response region"
Keywords:		"Animals Cadaverine/*pharmacology Extracellular Signal-Regulated MAP Kinases/metabolism Immunohistochemistry Microscopy, Fluorescence Odorants/analysis Olfactory Bulb/*metabolism/pathology Olfactory Receptor Neurons/*drug effects/metabolism Receptors, Odor;"
Notes:		"MedlineDieris, Milan Ahuja, Gaurav Krishna, Venkatesh Korsching, Sigrun I eng Research Support, Non-U.S. Gov't England 2017/01/20 Sci Rep. 2017 Jan 19; 7:40892. doi: 10.1038/srep40892"