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Curr Genet

Title:		"Rethinking the roles of CRP, cAMP, and sugar-mediated global regulation in the Vibrionaceae"
Author(s):		Colton DM; Stabb EV;
Address:		"Department of Microbiology, University of Georgia, 120 Cedar Street, Athens, GA, 30602, USA. Department of Microbiology, University of Georgia, 120 Cedar Street, Athens, GA, 30602, USA. estabb@uga.edu"
Journal Title:		Curr Genet
Year:		2016
Volume:		20150728
Issue:		1
Page Number:		39 - 45
DOI:		10.1007/s00294-015-0508-8
ISSN/ISBN:		1432-0983 (Electronic) 0172-8083 (Linking)
Abstract:		"Many proteobacteria modulate a suite of catabolic genes using the second messenger cyclic 3', 5'-AMP (cAMP) and the cAMP receptor protein (CRP). Together, the cAMP-CRP complex regulates target promoters, usually by activating transcription. In the canonical model, the phosphotransferase system (PTS), and in particular the EIIA(Glc) component for glucose uptake, provides a mechanistic link that modulates cAMP levels depending on glucose availability, resulting in more cAMP and activation of alternative catabolic pathways when glucose is unavailable. Within the Vibrionaceae, cAMP-CRP appears to play the classical role in modulating metabolic pathways; however, it also controls functions involved in natural competence, bioluminescence, pheromone signaling, and colonization of animal hosts. For this group of marine bacteria, chitin is an ecologically relevant resource, and chitin's monomeric sugar N-acetylglucosamine (NAG) supports robust growth while also triggering regulatory responses. Recent studies with Vibrio fischeri indicate that NAG and glucose uptake share EIIA(Glc), yet the responses of cAMP-CRP to these two carbon sources are starkly different. Moreover, control of cAMP levels appears to be more dominantly controlled by export and degradation. Perhaps more surprisingly, although CRP may require cAMP, its activity can be controlled in response to glucose by a mechanism independent of cAMP levels. Future studies in this area promise to shed new light on the role of cAMP and CRP"
Keywords:		*Carbohydrate Metabolism Cyclic AMP/*metabolism Cyclic AMP Receptor Protein/*metabolism Glucose/metabolism Vibrionaceae/*physiology Aliivibrio Cap Photobacterium Review;
Notes:		"MedlineColton, Deanna M Stabb, Eric V eng Research Support, U.S. Gov't, Non-P.H.S. Review 2015/07/29 Curr Genet. 2016 Feb; 62(1):39-45. doi: 10.1007/s00294-015-0508-8. Epub 2015 Jul 28"