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Sci Rep

Title:		Prediction and detection of human epileptic seizures based on SIFT-MS chemometric data
Author(s):		Catala A; Levasseur-Garcia C; Pages M; Schaff JL; Till U; Vitola Pasetto L; Hausberger M; Cousillas H; Violleau F; Grandgeorge M;
Address:		"Association Handi'Chiens, 13 Rue de l'Abbe Groult, Paris, France. amelie.catala@gmail.com. Univ Rennes, Normandie Univ, CNRS, EthoS (Ethologie animale et humaine), UMR 6552, 35000, Rennes, France. amelie.catala@gmail.com. Laboratoire de Chimie Agro-industrielle (LCA), Universite de Toulouse, INRA, University of Toulouse, National Polytechnic Institute of Toulouse, Ecole d'ingenieurs de Purpan, Toulouse, France. Equipe Physiologie, Pathologie et Genetique Vegetales (PPGV), University of Toulouse, National Polytechnic Institute of Toulouse, Ecole d'ingenieurs de Purpan, 75 voie du TOEC, BP 57611, 31076, Toulouse Cedex 03, France. Service de Neurologie du CHRU de Nancy, 29, avenue du Marechal de Lattre de Tassigny, Nancy, France. , Laval, France. Univ Rennes, Normandie Univ, CNRS, EthoS (Ethologie animale et humaine), UMR 6552, 35000, Rennes, France"
Journal Title:		Sci Rep
Year:		2020
Volume:		20201027
Issue:		1
Page Number:		18365 -
DOI:		10.1038/s41598-020-75478-8
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"Although epilepsy is considered a public health issue, the burden imposed by the unpredictability of seizures is mainly borne by the patients. Predicting seizures based on electroencephalography has had mixed success, and the idiosyncratic character of epilepsy makes a single method of detection or prediction for all patients almost impossible. To address this problem, we demonstrate herein that epileptic seizures can not only be detected by global chemometric analysis of data from selected ion flow tube mass spectrometry but also that a simple mathematical model makes it possible to predict these seizures (by up to 4 h 37 min in advance with 92% and 75% of samples correctly classified in training and leave-one-out-cross-validation, respectively). These findings should stimulate the development of non-invasive applications (e.g., electronic nose) for different types of epilepsy and thereby decrease of the unpredictability of epileptic seizures"
Keywords:		Breath Tests Humans Mass Spectrometry/*methods Odorants/*analysis Reproducibility of Results Seizures/*diagnosis/metabolism/physiopathology Sensitivity and Specificity Volatile Organic Compounds/*metabolism;
Notes:		"MedlineCatala, Amelie Levasseur-Garcia, Cecile Pages, Marielle Schaff, Jean-Luc Till, Ugo Vitola Pasetto, Leticia Hausberger, Martine Cousillas, Hugo Violleau, Frederic Grandgeorge, Marine eng Research Support, Non-U.S. Gov't England 2020/10/29 Sci Rep. 2020 Oct 27; 10(1):18365. doi: 10.1038/s41598-020-75478-8"