| Title: | WHOLE-meal ancient wheat-based diet: Effect on metabolic parameters and microbiota |
| Author(s): | Carroccio A; Celano G; Cottone C; Di Sclafani G; Vannini L; D'Alcamo A; Vacca M; Calabrese FM; Mansueto P; Soresi M; Francavilla R; De Angelis M; |
| Address: | "Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Via del Vespro, 141, Palermo 90100, Italy. Electronic address: antonio.carroccio@unipa.it. Department of Soil, Plant and Food Sciences, University 'Aldo Moro' of Bari, Via G. Amendola, 165/A, Bari 70126, Italy. General Practitioner, ASP 6 of Palermo, Palermo, Italy. Department of Agricultural and Food Sciences, Alma Mater Studiorum University of Bologna, Viale G. Fanin, 42, Bologna 40127, Italy. Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Via del Vespro, 141, Palermo 90100, Italy. Department of Biomedical Science and Human Oncology, University 'Aldo Moro' of Bari, Piazza Giulio Cesare, 11, Bari 70124, Italy" |
| DOI: | 10.1016/j.dld.2021.04.026 |
| ISSN/ISBN: | 1878-3562 (Electronic) 1590-8658 (Linking) |
| Abstract: | "BACKGROUND & AIMS: Ancient wheat varieties are considered to be healthier than modern ones, but the data are not univocal. We investigated changes in hematochemical parameters and evaluated microbiota data before and after a set period on a diet containing a whole-meal ancient wheat mix. PATIENTS AND METHODS: 29 cloistered nuns were recruited. The study comprised two consecutive 30-day periods; during the first one (T1), the nuns received wheat-based foods produced with refined 'modern' flour ('Simeto'); during the second one (T2) received wheat-based foods produced with an unrefined flour mix composed of 'ancient' cultivars. At entry to the study (T0) and at the end of T1 and T2 hematochemical parameters and fecal microbiota and metabolome were evaluated. RESULTS: At the end of T2, there was a significant reduction in serum iron, ferritin, creatinine, sodium, potassium, magnesium, total cholesterol, LDL- and HDL-cholesterol and folic acid. Furthermore, increased the abundance of cultivable enterococci, lactic acid bacteria and total anaerobes. The ability of the gut microbiome to metabolize carbohydrates increased after the period of diet containing ancient grain products. Several volatile organic compounds increased after the one month on the diet enriched with ancient grain products. CONCLUSIONS: Our data showed the beneficial effects deriving from a diet including ancient whole-meal/unrefined wheat flours" |
| Keywords: | Adult Aged Diet Feces/microbiology Female *Gastrointestinal Microbiome Humans Middle Aged *Triticum Ancient wheat Whole-meal wheat; |
| Notes: | "MedlineCarroccio, Antonio Celano, Giuseppe Cottone, Carmelo Di Sclafani, Giuseppe Vannini, Lucia D'Alcamo, Alberto Vacca, Mirco Calabrese, Francesco Maria Mansueto, Pasquale Soresi, Maurizio Francavilla, Ruggiero De Angelis, Maria eng Netherlands 2021/05/25 Dig Liver Dis. 2021 Nov; 53(11):1412-1421. doi: 10.1016/j.dld.2021.04.026. Epub 2021 May 20" |
