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StatPearls

Title:		Trimethylaminuria
Author(s):		Awosika AO; Anastasopoulou C;
Address:		University of Illinois College of Medicine Einstein Medical Center
Journal Title:		StatPearls
Year:		2023
Volume:
Issue:
Page Number:		-
DOI:
ISSN/ISBN:
Abstract:		"Trimethylaminuria (TMAU), also known as fish odor syndrome or stale fish syndrome, is a rare metabolic disorder characterized by the abnormal accumulation and excretion of trimethylamine (TMA). The accumulation of TMA results in a strong, offensive odor resembling that of rotting fish. The underlying pathogenesis of TMAU is usually a deficient or dysfunctional hepatic enzyme, flavin-containing monooxygenase 3 (FMO3). This enzyme metabolizes TMA into an odorless compound, trimethylamine N-oxide (TMAO). TMA has a strong fishy smell and is a pheromone in different organisms. A case report described this condition in 1970, but it is believed that trimethylaminuria had been in existence long before then"
Keywords:
Notes:		"engAwosika, Ayoola O Anastasopoulou, Catherine Study Guide Book Chapter"