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Cell Cycle

Title:		Spatial segregation of Ras signaling: new evidence from fission yeast
Author(s):		Chang EC; Philips MR;
Address:		"Baylor College of Medicine, Department of Molecular and Cell Biology, The Breast Center, Houston, Texas 77030, USA. echang@breastcenter.tmc.edu"
Journal Title:		Cell Cycle
Year:		2006
Volume:		20060901
Issue:		17
Page Number:		1936 - 1939
DOI:		10.4161/cc.5.17.3187
ISSN/ISBN:		1551-4005 (Electronic) 1538-4101 (Print) 1551-4005 (Linking)
Abstract:		"The Ras GTPases act as binary switches for signal transduction pathways that are important for growth regulation and tumorigenesis. Despite the biochemical simplicity of this switch, Ras proteins control multiple pathways, and the functions of the four mammalian Ras proteins are not overlapping. This raises an important question--how does a Ras protein selectively regulate a particular activity? One recently emerging model suggests that a single Ras protein can control different functions by acting in distinct cellular compartments. A critical test of this model is to identify pathways that are selectively controlled by Ras when it is localized to a particular compartment. A recent study has examined Ras signaling in the fission yeast Schizosaccharomyces pombe, which expresses only one Ras protein that controls two separate evolutionarily conserved pathways. This study demonstrates that whereas Ras localized to the plasma membrane selectively regulates a MAP kinase pathway to mediate mating pheromone signaling, Ras localized to the endomembrane activates a Cdc42 pathway to mediate cell polarity and protein trafficking. This study has provided unambiguous evidence for compartmentalized signaling of Ras"
Keywords:		Amino Acid Sequence Cell Compartmentation Molecular Sequence Data Schizosaccharomyces/chemistry/*metabolism Schizosaccharomyces pombe Proteins/analysis/chemistry/*metabolism *Signal Transduction ras Proteins/analysis/chemistry/*metabolism;
Notes:		"MedlineChang, Eric C Philips, Mark R eng CA116034/CA/NCI NIH HHS/ R01 GM055279/GM/NIGMS NIH HHS/ R01 CA116034/CA/NCI NIH HHS/ R01 CA107187-04/CA/NCI NIH HHS/ R01 CA090464/CA/NCI NIH HHS/ GM55279/GM/NIGMS NIH HHS/ R01 CA090464-05/CA/NCI NIH HHS/ R01 CA090464-06/CA/NCI NIH HHS/ R01 CA107187/CA/NCI NIH HHS/ CA90464/CA/NCI NIH HHS/ R01 CA118495/CA/NCI NIH HHS/ CA118495/CA/NCI NIH HHS/ CA107187/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review 2006/08/26 Cell Cycle. 2006 Sep; 5(17):1936-9. doi: 10.4161/cc.5.17.3187. Epub 2006 Sep 1"