| Title: | Exhaled volatile substances in children suffering from type 1 diabetes mellitus: results from a cross-sectional study |
| Author(s): | Trefz P; Obermeier J; Lehbrink R; Schubert JK; Miekisch W; Fischer DC; |
| Address: | "Department of Anesthesiology and Intensive Care Medicine, Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Rostock University Medical Centre, Rostock, Germany. phillip.trefz@uni-rostock.de. Department of Anesthesiology and Intensive Care Medicine, Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Rostock University Medical Centre, Rostock, Germany. Department of Pediatrics, Rostock University Medical Centre, Rostock, Germany" |
| DOI: | 10.1038/s41598-019-52165-x |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Monitoring metabolic adaptation to type 1 diabetes mellitus in children is challenging. Analysis of volatile organic compounds (VOCs) in exhaled breath is non-invasive and appears as a promising tool. However, data on breath VOC profiles in pediatric patients are limited. We conducted a cross-sectional study and applied quantitative analysis of exhaled VOCs in children suffering from type 1 diabetes mellitus (T1DM) (n = 53) and healthy controls (n = 60). Both groups were matched for sex and age. For breath gas analysis, a very sensitive direct mass spectrometric technique (PTR-TOF) was applied. The duration of disease, the mode of insulin application (continuous subcutaneous insulin infusion vs. multiple daily insulin injection) and long-term metabolic control were considered as classifiers in patients. The concentration of exhaled VOCs differed between T1DM patients and healthy children. In particular, T1DM patients exhaled significantly higher amounts of ethanol, isopropanol, dimethylsulfid, isoprene and pentanal compared to healthy controls (171, 1223, 19.6, 112 and 13.5 ppbV vs. 82.4, 784, 11.3, 49.6, and 5.30 ppbV). The most remarkable differences in concentrations were found in patients with poor metabolic control, i.e. those with a mean HbA(1c) above 8%. In conclusion, non-invasive breath testing may support the discovery of basic metabolic mechanisms and adaptation early in the progress of T1DM" |
| Keywords: | "Adolescent *Breath Tests Case-Control Studies Child Child, Preschool Cross-Sectional Studies Diabetes Mellitus, Type 1/*metabolism Female Humans Male Volatile Organic Compounds/*analysis;" |
| Notes: | "MedlineTrefz, Phillip Obermeier, Juliane Lehbrink, Ruth Schubert, Jochen K Miekisch, Wolfram Fischer, Dagmar-Christiane eng Research Support, Non-U.S. Gov't England 2019/11/02 Sci Rep. 2019 Oct 31; 9(1):15707. doi: 10.1038/s41598-019-52165-x" |
