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Angew Chem Int Ed Engl

Title:		Complex small-molecule architectures regulate phenotypic plasticity in a nematode
Author(s):		Bose N; Ogawa A; von Reuss SH; Yim JJ; Ragsdale EJ; Sommer RJ; Schroeder FC;
Address:		"Boyce Thompson Institute and Department of Chemistry, Cornell University, Ithaca, NY, USA"
Journal Title:		Angew Chem Int Ed Engl
Year:		2012
Volume:		20121119
Issue:		50
Page Number:		12438 - 12443
DOI:		10.1002/anie.201206797
ISSN/ISBN:		1521-3773 (Electronic) 1433-7851 (Print) 1433-7851 (Linking)
Abstract:		"Chemistry the worm's way: The nematode Pristionchus pacificus constructs elaborate small molecules from modified building blocks of primary metabolism, including an unusual xylopyranose-based nucleoside (see scheme). These compounds act as signaling molecules to control adult phenotypic plasticity and dauer development and provide examples of modular generation of structural diversity in metazoans"
Keywords:		Amino Acids/chemistry/metabolism Animals Caenorhabditis elegans/metabolism Fatty Acids/metabolism Metabolome Nematoda/*metabolism Nucleosides/chemistry/metabolism Pheromones/chemistry/metabolism Signal Transduction Transcription Factors/metabolism Xylose/;
Notes:		"MedlineBose, Neelanjan Ogawa, Akira von Reuss, Stephan H Yim, Joshua J Ragsdale, Erik J Sommer, Ralf J Schroeder, Frank C eng R01 GM085285/GM/NIGMS NIH HHS/ R01 GM088290/GM/NIGMS NIH HHS/ GM085285/GM/NIGMS NIH HHS/ GM088290/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Germany 2012/11/20 Angew Chem Int Ed Engl. 2012 Dec 7; 51(50):12438-43. doi: 10.1002/anie.201206797. Epub 2012 Nov 19"