| Title: | Natural menstrual rhythm and oral contraception diversely affect exhaled breath compositions |
| Author(s): | Sukul P; Schubert JK; Trefz P; Miekisch W; |
| Address: | "Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Dept. of Anesthesiology and Intensive Care, University Medicine Rostock, Schillingallee 35, D-18057, Rostock, Germany. pritam.sukul@uni-rostock.de. Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Dept. of Anesthesiology and Intensive Care, University Medicine Rostock, Schillingallee 35, D-18057, Rostock, Germany" |
| DOI: | 10.1038/s41598-018-29221-z |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Natural menstrual cycle and/or oral contraception diversely affect women metabolites. Longitudinal metabolic profiling under constant experimental conditions is thereby realistic to understand such effects. Thus, we investigated volatile organic compounds (VOCs) exhalation throughout menstrual cycles in 24 young and healthy women with- and without oral contraception. Exhaled VOCs were identified and quantified in trace concentrations via high-resolution real-time mass-spectrometry, starting from a menstruation and then repeated follow-up with six intervals including the next bleeding. Repeated measurements within biologically comparable groups were employed under optimized measurement setup. We observed pronounced and substance specific changes in exhaled VOC concentrations throughout all cycles with low intra-individual variations. Certain blood-borne volatiles changed significantly during follicular and luteal phases. Most prominent changes in endogenous VOCs were observed at the ovulation phase with respect to initial menstruation. Here, the absolute median abundances of alveolar ammonia, acetone, isoprene and dimethyl sulphide changed significantly (P-value |
| Keywords: | "Adolescent Adult Breath Tests Contraception/*methods Contraceptives, Oral/*administration & dosage Exhalation/*physiology Female Humans Menstruation/*physiology Middle Aged Respiratory Physiological Phenomena Volatile Organic Compounds/*analysis Young Adu;" |
| Notes: | "MedlineSukul, Pritam Schubert, Jochen K Trefz, Phillip Miekisch, Wolfram eng 643694/EC | Horizon 2020 (European Union Framework Programme for Research and Innovation)/International Research Support, Non-U.S. Gov't England 2018/07/20 Sci Rep. 2018 Jul 18; 8(1):10838. doi: 10.1038/s41598-018-29221-z" |
