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Toxicol Sci


Title:Increased volume of the calbindin D28k-labeled sexually dimorphic hypothalamus in genistein and nonylphenol-treated male rats
Author(s):Scallet AC; Divine RL; Newbold RR; Delclos KB;
Address:"Division of Neurotoxicology National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA. ascallet@nctr.fda.gov"
Journal Title:Toxicol Sci
Year:2004
Volume:20040929
Issue:2
Page Number:570 - 576
DOI: 10.1093/toxsci/kfh297
ISSN/ISBN:1096-6080 (Print) 1096-0929 (Linking)
Abstract:"The adult rat brain develops through an interplay of neuronal proliferation and programmed cell death. Steroid hormones and growth factors may alter the balance between these competing processes. 'Endocrine disrupters' (EDs) may also alter brain development, by mimicry or modulation of endogenous hormone systems. Under control conditions, the sexually dimorphic nucleus (SDN) of the medial preoptic hypothalamus becomes larger in adult males than females, but its final volume may also reflect the hormonal conditions prevailing during development. Two EDs that have recently been studied in protocols involving lifespan exposures are the phytoestrogen genistein and the weakly estrogenic compound para-nonylphenol, which is used in the production of many surfactants and plastics. Experimental dietary exposure of adult female rats to genistein or p-nonylphenol began 28 days prior to their mating at concentrations of 5 ppm, 100 ppm, and 500 ppm for genistein or 25 ppm, 200 ppm, and 750 ppm for p-nonylphenol. Exposure of the offspring continued throughout gestation and lactation, as well as in their chow after weaning, until they were sacrificed at 140 days of age for immunohistochemical labeling of the calbindin D28k-labeled subdivision of the SDN: the CALB-SDN. Both genistein and nonylphenol were found to increase the volume of the CALB-SDN in male rats (p's < 0.01), but not in female rats"
Keywords:"Animals Biomarkers Calbindin 1 Calbindins Coloring Agents Diet Dose-Response Relationship, Drug Estrogens, Non-Steroidal/*pharmacology Female Genistein/*pharmacology Hypothalamus/drug effects/*metabolism Image Processing, Computer-Assisted Male Phenols/*p;"
Notes:"MedlineScallet, A C Divine, R L Newbold, R R Delclos, K B eng Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 2004/10/01 Toxicol Sci. 2004 Dec; 82(2):570-6. doi: 10.1093/toxsci/kfh297. Epub 2004 Sep 29"

 
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