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J Bacteriol

Title:		Competence for genetic transformation in encapsulated strains of Streptococcus pneumoniae: two allelic variants of the peptide pheromone
Author(s):		Pozzi G; Masala L; Iannelli F; Manganelli R; Havarstein LS; Piccoli L; Simon D; Morrison DA;
Address:		"Sezione di Microbiologia, Dipartimento di Scienze Chirurgiche, Universita di Cagliara, Italy. pozzi@unica.it"
Journal Title:		J Bacteriol
Year:		1996
Volume:		178
Issue:		20
Page Number:		6087 - 6090
DOI:		10.1128/jb.178.20.6087-6090.1996
ISSN/ISBN:		0021-9193 (Print) 1098-5530 (Electronic) 0021-9193 (Linking)
Abstract:		"The nucleotide sequence of comC, the gene encoding the 17-residue competence-stimulating peptide (CSP) of Streptococcus pneumoniae (L. S. Havarstein, G. Coomaraswamy, and D. A. Morrison, Proc. Natl. Acad. Sci. USA 92:11140-11144, 1995) was determined with 42 encapsulated strains of different serotypes. A new allele, comC2, was found in 13 strains, including the type 3 Avery strain, A66, while all others carried a gene (now termed comC1) identical to that originally described for strain Rx1. The predicted mature product of comC2 is also a heptadecapeptide but differs from that of comC1 at eight residues. Both CSP-1 and CSP-2 synthetic peptides were used to induce competence in the 42 strains; 48% of the strains became competent after the addition of the synthetic peptide, whereas none were transformable without the added peptides"
Keywords:		Alleles Amino Acid Sequence Bacterial Capsules Bacterial Proteins/*genetics Base Sequence DNA-Binding Proteins/*genetics *Genetic Variation Molecular Sequence Data Pheromones/*genetics Sequence Homology Species Specificity Streptococcus pneumoniae/*geneti;
Notes:		"MedlinePozzi, G Masala, L Iannelli, F Manganelli, R Havarstein, L S Piccoli, L Simon, D Morrison, D A eng Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 1996/10/01 J Bacteriol. 1996 Oct; 178(20):6087-90. doi: 10.1128/jb.178.20.6087-6090.1996"