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Science

Title:		Clathrin: a role in the intracellular retention of a Golgi membrane protein
Author(s):		Payne GS; Schekman R;
Address:		"Department of Biological Chemistry, UCLA School of Medicine 90024"
Journal Title:		Science
Year:		1989
Volume:		245
Issue:		4924
Page Number:		1358 - 1365
DOI:		10.1126/science.2675311
ISSN/ISBN:		0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"Yeast mutants deficient in the clathrin heavy chain secrete a precursor form of the alpha-factor, a peptide-mating pheromone. Analysis of this defect indicates that the endoprotease Kex2p, which is responsible for initiating proteolytic maturation of the alpha-factor precursor in the Golgi apparatus, is unexpectedly present at the plasma membrane in mutant cells. This result suggest that clathrin is required for the retention of Kex2p in the Golgi apparatus"
Keywords:		"Cell Compartmentation Clathrin/*physiology Golgi Apparatus/*physiology Intracellular Membranes/*physiology Mating Factor Membrane Proteins/*physiology Peptide Hydrolases/metabolism Peptides/metabolism Protein Precursors/metabolism Protein Processing, Post;"
Notes:		"MedlinePayne, G S Schekman, R eng GM 36881/GM/NIGMS NIH HHS/ GM 39040/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1989/09/22 Science. 1989 Sep 22; 245(4924):1358-65. doi: 10.1126/science.2675311"