| Title: | Biosynthesis of Oligopeptides Using ATP-Grasp Enzymes |
| Address: | "Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan" |
| ISSN/ISBN: | 1521-3765 (Electronic) 0947-6539 (Linking) |
| Abstract: | "Peptides are biologically occurring oligomers of amino acids linked by amide bonds and are indispensable for all living organisms. Many bioactive peptides are used as antibiotics, antivirus agents, insecticides, pheromones, and food preservatives. Nature employs several different strategies to form amide bonds. ATP-grasp enzymes that catalyze amide bond formation (ATP-dependent carboxylate-amine ligases) utilize a strategy of activating carboxylic acid as an acylphosphate intermediate to form amide bonds and are involved in many different biological processes in both primary and secondary metabolisms. The recent discovery of several new ATP-dependent carboxylate-amine ligases has expanded the diversity of this group of enzymes and showed their usefulness for generating oligopeptides. In this review, an overview of findings on amide bond formation catalyzed by ATP-grasp enzymes in the past decade is presented" |
| Keywords: | Adenosine Triphosphate/metabolism Amidinotransferases/metabolism Carboxypeptidases/*metabolism Cobalt/chemistry Cyclization Drug Combinations Methionine/biosynthesis/chemistry Oligopeptides/*biosynthesis/chemistry Peptide Synthases/metabolism ATP-grasp am; |
| Notes: | "MedlineOgasawara, Yasushi Dairi, Tohru eng Review Germany 2017/05/11 Chemistry. 2017 Aug 10; 23(45):10714-10724. doi: 10.1002/chem.201700674. Epub 2017 Jun 23" |
