| Title: | Estimation of dermal and oral exposure of children to scented toys: analysis of the migration of fragrance allergens by dynamic headspace GC-MS |
| Author(s): | Masuck I; Hutzler C; Luch A; |
| Address: | "Department of Product Safety, German Federal Institute for Risk Assessment, Berlin, Germany. ines.masuck@bfr.bund.de" |
| ISSN/ISBN: | 1615-9314 (Electronic) 1615-9306 (Linking) |
| Abstract: | "Fragrances capable of inducing contact allergy in skin potentially can migrate from the toy to the child via oral or dermal contacts. The goal of this work was the developing of an analytical method based on dynamic headspace GC-MS to determine the concentration of 24 fragrances in saliva or sweat simulant. Under optimized conditions, 5 mL of the migration simulant with 2 g sodium chloride were incubated for 10 min at 30 degrees C. The headspace was purged at a flow rate of 50 mL/min. The compounds were quantified by internal calibration resulting in good linearity (>0.991). The recovery was greater than 66.3% for most of the compounds. The limits of detection ranged between 0.5 ng/mL for hydrophobic and 196.0 ng/mL for hydrophilic fragrances. The method was subsequently applied to seven real toys purchased from the market. The highest migration rate could be observed for benzyl benzoate with 268.0 ng/cm(2)/min. Based on the migration data measured, the ranges of dermal and oral exposure of children to fragrances in scented toys were calculated. The maximum oral and dermal exposure levels were estimated at 22.2 mug per kg body weight (BW) and day (d) for benzyl benzoate and 605.0 mug/kg BW/d for benzyl alcohol, respectively" |
| Keywords: | Air Pollutants/*analysis/toxicity Allergens/*analysis/toxicity Child Female Gas Chromatography-Mass Spectrometry/*methods Humans Hypersensitivity/prevention & control Inhalation Exposure/*adverse effects Male Mouth/drug effects *Play and Playthings Skin/d; |
| Notes: | "MedlineMasuck, Ines Hutzler, Christroph Luch, Andreas eng Evaluation Study Research Support, Non-U.S. Gov't Germany 2011/09/08 J Sep Sci. 2011 Oct; 34(19):2686-96. doi: 10.1002/jssc.201100360. Epub 2011 Aug 24" |
