| Title: | "Cross-generational impact of a male murine pheromone 2-sec-butyl-4,5- dihydrothiazole in female mice" |
| Author(s): | Koyama S; Soini HA; Wager-Miller J; Alley WR; Pizzo MJ; Rodda C; Alberts J; Crystal JD; Lai C; Foley J; Novotny MV; |
| ISSN/ISBN: | 1471-2954 (Electronic) 0962-8452 (Print) 0962-8452 (Linking) |
| Abstract: | "The current understanding of the activity of mammalian pheromones is that endocrine and behavioural effects are limited to the exposed individuals. Here, we demonstrate that the nasal exposure of female mice to a male murine pheromone stimulates expansion of mammary glands, leading to prolonged nursing of pups. Subsequent behavioural testing of the pups from pheromone-exposed dams exhibited enhanced learning. Sialic acid components in the milk are known to be involved in brain development. We hypothesized that the offspring might have received more of this key nutrient that promotes brain development. The mRNA for polysialyltransferase, which produces polysialylated neural cell adhesion molecules related to brain development,was increased in the brain of offspring of pheromone-exposed dams at post-natal day 10, while it was not different at embryonic stages, indicating possible differential brain development during early post-natal life" |
| Keywords: | "Animals Cognition/*drug effects Female Male Mammary Glands, Animal/*drug effects/growth & development Mice/growth & development/*physiology Mice, Inbred C57BL Pheromones/*metabolism Thiazoles/*metabolism;" |
| Notes: | "MedlineKoyama, Sachiko Soini, Helena A Wager-Miller, James Alley, William R Pizzo, Matthew J Rodda, Cathleen Alberts, Jeffrey Crystal, Jonathon D Lai, Cary Foley, John Novotny, Milos V eng 1R43MH094130-01/MH/NIMH NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2015/07/03 Proc Biol Sci. 2015 Jul 22; 282(1811):20151074. doi: 10.1098/rspb.2015.1074" |
