| Title: | Alarm pheromone enhances stress-induced hyperthermia in rats |
| Author(s): | Kikusui T; Takigami S; Takeuchi Y; Mori Y; |
| Address: | "Laboratory of Veterinary Ethology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. akikus@mail.ecc.u-tokyo.ac.jp" |
| DOI: | 10.1016/s0031-9384(00)00370-x |
| ISSN/ISBN: | 0031-9384 (Print) 0031-9384 (Linking) |
| Abstract: | "Behavioral and physiological effects of alarm pheromones emanating from stressed conspecific animals were investigated. Experimentally naive male Wistar rats were exposed to the test chambers containing alarm pheromones, which had been released by other rats receiving foot shocks in the same chamber beforehand. Along with behavioral analysis, the heart rate (HR) and core body temperature (cBT) were measured simultaneously using a biotelemetory system. Exposure to the alarm pheromones increased freezing, sniffing and walking and decreased resting as compared with rats exposed to control odors. In addition, these pheromone-exposed animals showed consistent increases in body temperature, i.e., stress-induced hyperthermia. After exposure to the alarm substances, immunoreactivity to nuclear Fos protein in the mitral cell layer in the accessory olfactory bulb (AOB) also increased compared with the reaction to control odors. These results suggest that an alarm pheromone enhances stress responses of conspecific animals both behaviorally and physiologically, and that these effects are mediated via activation of the AOB" |
| Keywords: | "Animals Behavior, Animal/drug effects/physiology Body Temperature/drug effects/physiology Fever/*physiopathology Heart Rate/drug effects/physiology Immunohistochemistry Male Olfactory Bulb/drug effects/metabolism Pheromones/*pharmacology Proto-Oncogene Pr;" |
| Notes: | "MedlineKikusui, T Takigami, S Takeuchi, Y Mori, Y eng Research Support, Non-U.S. Gov't 2001/03/10 Physiol Behav. 2001 Jan; 72(1-2):45-50. doi: 10.1016/s0031-9384(00)00370-x" |
