| Title: | Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus project |
| Author(s): | Karlson EW; Watts J; Signorovitch J; Bonetti M; Wright E; Cooper GS; McAlindon TE; Costenbader KH; Massarotti EM; Fitzgerald LM; Jajoo R; Husni ME; Fossel AH; Pankey H; Ding WZ; Knorr R; Condon S; Fraser PA; |
| Address: | "Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. ekarlson@partners.org" |
| ISSN/ISBN: | 0004-3591 (Print) 0004-3591 (Linking) |
| Abstract: | "OBJECTIVE: The high prevalence of systemic lupus erythematosus (SLE) among African American women may be due to environmental exposures, genetic factors, or a combination of factors. Our goal was to assess association of residential proximity to hazardous waste sites and genetic variation in 3 glutathione Stransferase (GST) genes (GSTM1, GSTT1, and GSTP1) with age at diagnosis of SLE. METHODS: Residential histories were obtained by interviewing 93 SLE patients from 3 predominantly African American neighborhoods in Boston. Residential addresses and locations of 416 hazardous waste sites in the study area were geocoded using ArcView software. Time-varying Cox models were used to study the effect of residential proximity to hazardous sites, GST genotype, and interaction between genotype and exposure in determining age at diagnosis. RESULTS: The prevalence of SLE among African American women in these neighborhoods was 3.56 SLE cases per 1,000. Homozygosity for GSTM1-null and GSTP1 Ile105Val in combination was associated with earlier SLE diagnosis (P = 0.03), but there was no association with proximity to 416 hazardous sites. Available data on specific site contaminants suggested that, at a subset of 67 sites, there was higher potential risk for exposure to volatile organic compounds (P < 0.05 with Bonferroni correction). GST genotypes had a significant interaction with proximity (P = 0.03) in analyses limited to these sites. CONCLUSION: There was no independent association between residential proximity to hazardous waste sites and the risk of earlier SLE diagnosis in this urban population. However, analysis of a limited number of sites indicated that the risk of earlier SLE associated with proximity to hazardous sites might be modulated by GST polymorphisms" |
| Keywords: | Adolescent Adult Black or African American/ethnology/statistics & numerical data Aged Boston/epidemiology Environmental Exposure/*adverse effects Female *Genetic Predisposition to Disease Genotype Glutathione Transferase/*genetics Hazardous Waste/*adverse; |
| Notes: | "MedlineKarlson, Elizabeth W Watts, Julie Signorovitch, James Bonetti, Marco Wright, Elizabeth Cooper, Glinda S McAlindon, Timothy E Costenbader, Karen H Massarotti, Elena M Fitzgerald, Lisa M Jajoo, Ramina Husni, M Elaine Fossel, Anne H Pankey, Helen Ding, Wei-Zi Knorr, Robert Condon, Suzanne Fraser, Patricia A eng P60-AR-47782/AR/NIAMS NIH HHS/ R01-AR-49880/AR/NIAMS NIH HHS/ R25-ES-10457-01/ES/NIEHS NIH HHS/ Intramural NIH HHS/ Multicenter Study Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't 2006/12/30 Arthritis Rheum. 2007 Jan; 56(1):244-54. doi: 10.1002/art.22308" |
