| Title: | Mammalian carboxylesterase 5: comparative biochemistry and genomics |
| Author(s): | Holmes RS; Cox LA; Vandeberg JL; |
| Address: | "Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA" |
| Journal Title: | Comp Biochem Physiol Part D Genomics Proteomics |
| DOI: | 10.1016/j.cbd.2008.05.002 |
| ISSN/ISBN: | 1878-0407 (Electronic) 1744-117X (Print) 1744-117X (Linking) |
| Abstract: | "Carboxylesterase 5 (CES5) (also called cauxin or CES7) is one of at least five mammalian CES gene families encoding enzymes of broad substrate specificity and catalysing hydrolytic and transesterification reactions. In silico methods were used to predict the amino acid sequences, secondary structures and gene locations for CES5 genes and gene products. Amino acid sequence alignments of mammalian CES5 enzymes enabled identification of key CES sequences previously reported for human CES1, as well as other sequences that are specific to the CES5 gene family, which were consistent with being monomeric in subunit structure and available for secretion into body fluids. Predicted secondary structures for mammalian CES5 demonstrated significant conservation with human CES1 as well as distinctive mammalian CES5 like structures. Mammalian CES5 genes are located in tandem with the CES1 gene(s), are transcribed on the reverse strand and contained 13 exons. CES5 has been previously reported in high concentrations in the urine (cauxin) of adult male cats, and within a protein complex of mammalian male epididymal fluids. Roles for CES5 may include regulating urinary levels of male cat pheromones; catalysing lipid transfer reactions within mammalian male reproductive fluids; and protecting neural tissue from drugs and xenobiotics" |
| Keywords: | Ces5 Mammals amino acid sequence carboxylesterase drug detoxification genomics; |
| Notes: | "PubMed-not-MEDLINEHolmes, Roger S Cox, Laura A Vandeberg, John L eng C06 RR017515/RR/NCRR NIH HHS/ C06 RR013556/RR/NCRR NIH HHS/ P01 HL028972/HL/NHLBI NIH HHS/ P51 RR013986-020044/RR/NCRR NIH HHS/ P01 HL028972-18/HL/NHLBI NIH HHS/ C06 RR015456/RR/NCRR NIH HHS/ P51 RR013986/RR/NCRR NIH HHS/ Netherlands 2009/09/04 Comp Biochem Physiol Part D Genomics Proteomics. 2008 Sep; 3(3):195-204. doi: 10.1016/j.cbd.2008.05.002" |
