| Title: | [Impact of Ph-SA on the expression of delta-toxin in Staphylococcus aureus] |
| Author(s): | Guo L; Zhang J; Tang XY; Qiu XQ; |
| Address: | "Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China" |
| Journal Title: | Sichuan Da Xue Xue Bao Yi Xue Ban |
| ISSN/ISBN: | 1672-173X (Print) 1672-173X (Linking) |
| Abstract: | "OBJECTIVE: We carried out this pilot study in an attempt to observe the effect of Ph-SA on the secretion of delta-toxin in S. aureus ATCC29213. METHODS: When A595 reaching about 0. 2, the bacteria were divided into three groups and were treated by PBS, penicillin and Ph-SA respectively. The amount of delta-toxin from different groups and growth phases was analyzed by high performance liquid chromatography. RESULTS: It was observed that the secretion of delta-toxin in Ph-SA group was less than that in the other two groups at the same time (P < 0.05). CONCLUSION: We postulate that Ph-SA has the negative effect on the activity of agr system, acting as a pseudo-ligand" |
| Keywords: | Bacterial Proteins/*genetics/*pharmacology Bacterial Toxins/*biosynthesis Humans Pheromones/genetics/*pharmacology Pilot Projects Staphylococcus aureus/*drug effects/metabolism Trans-Activators/*genetics/*pharmacology; |
| Notes: | "MedlineGuo, Li Zhang, Jie Tang, Xiao-yan Qiu, Xiao-qing chi English Abstract Research Support, Non-U.S. Gov't China 2005/06/04 Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 May; 36(3):312-4" |
