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Anal Bioanal Chem

Title:		Bioanalytical separation and preconcentration using ionic liquids
Author(s):		Escudero LB; Castro Grijalba A; Martinis EM; Wuilloud RG;
Address:		"Laboratory of Analytical Chemistry for Research and Development (QUIANID), Instituto de Ciencias Basicas, Universidad Nacional de Cuyo, Padre J. Contreras 1300, Parque Gral. San Martin, M5502JMA, Mendoza, Argentina"
Journal Title:		Anal Bioanal Chem
Year:		2013
Volume:		20130517
Issue:		24
Page Number:		7597 - 7613
DOI:		10.1007/s00216-013-6950-x
ISSN/ISBN:		1618-2650 (Electronic) 1618-2642 (Linking)
Abstract:		"Ionic liquids (ILs) are novel solvents that display a number of unique properties, such as negligible vapor pressure, thermal stability (even at high temperatures), favorable viscosity, and miscibility with water and organic solvents. These properties make them attractive alternatives to environmentally unfriendly solvents that produce volatile organic compounds. In this article, a critical review of state-of-the-art developments in the use of ILs for the separation and preconcentration of bioanalytes in biological samples is presented. Special attention is paid to the determination of various organic and inorganic analytes--including contaminants (e.g., pesticides, nicotine, opioids, gold, arsenic, lead, etc.) and functional biomolecules (e.g., testosterone, vitamin B12, hemoglobin)--in urine, blood, saliva, hair, and nail samples. A brief introduction to modern microextraction techniques based on ILs, such as dispersive liquid-liquid microextraction (DLLME) and single-drop microextraction (SDME), is provided. A comparison of IL-based methods in terms of their limits of detection and environmental compatibilities is also made. Finally, critical issues and challenges that have arisen from the use of ILs in separation and preconcentration techniques are also discussed"
Keywords:		"Biological Assay/*trends Chemical Fractionation/*methods Chemistry, Analytic/*trends Ionic Liquids/*chemistry Liquid Phase Microextraction/*methods Solvents/chemistry;"
Notes:		"MedlineEscudero, Leticia B Castro Grijalba, Alexander Martinis, Estefania M Wuilloud, Rodolfo G eng Research Support, Non-U.S. Gov't Review Germany 2013/05/18 Anal Bioanal Chem. 2013 Sep; 405(24):7597-613. doi: 10.1007/s00216-013-6950-x. Epub 2013 May 17"