| Title: | Detection of presymptomatic Alzheimer's disease through breath biomarkers |
| Author(s): | Emam S; Nasrollahpour M; Colarusso B; Cai X; Grant S; Kulkarni P; Ekenseair A; Gharagouzloo C; Ferris CF; Sun NX; |
| Address: | Department of Electrical and Computer Engineering Advanced Materials and Microsystems Laboratory Northeastern University Boston Massachusetts USA. Department of Psychology Center for Translational NeuroImaging Northeastern University Boston Massachusetts USA. Department of Chemical Engineering Northeastern University Boston Massachusetts USA. Imaginostics Inc. Northeastern University Cambridge Massachusetts USA |
| ISSN/ISBN: | 2352-8729 (Print) 2352-8729 (Electronic) 2352-8729 (Linking) |
| Abstract: | "INTRODUCTION: Novel sensors were developed to detect exhaled volatile organic compounds to aid in the diagnosis of mild cognitive impairment associated with early stage Alzheimer's disease (AD). The sensors were sensitive to a rat model that combined the human apolipoprotein E (APOE)4 gene with aging and the Western diet. METHODS: Gas sensors fabricated from molecularly imprinted polymer-graphene were engineered to react with alkanes and small fatty acids associated with lipid peroxidation. With a detection sensitivity in parts per trillion the sensors were tested against the breath of wild-type and APOE4 male rats. Resting state BOLD functional connectivity was used to assess hippocampal function. RESULTS: Only APOE4 rats, and not wild-type controls, tested positive to several small hydrocarbons and presented with reduced functional coupling in hippocampal circuitry. DISCUSSION: These results are proof-of-concept toward the development of sensors that can be used as breath detectors in the diagnosis, prognosis, and treatment of presymptomatic AD" |
| Keywords: | "2, 3-dimethylheptane Apoe4 Western diet butylated hydroxytoluene electrochemical polymerization hippocampal circuitry imprinted polymer-graphene lipid peroxidation pivalic acid resting state functional connectivity silicon substrate;" |
| Notes: | "PubMed-not-MEDLINEEmam, Shadi Nasrollahpour, Mehdi Colarusso, Bradley Cai, Xuezhu Grant, Simone Kulkarni, Praveen Ekenseair, Adam Gharagouzloo, Codi Ferris, Craig F Sun, Nian-Xiang eng 2020/10/23 Alzheimers Dement (Amst). 2020 Oct 14; 12(1):e12088. doi: 10.1002/dad2.12088. eCollection 2020" |
