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Biopolymers

Title:		Insect neuropeptide antagonists
Author(s):		Altstein M;
Address:		"Institute of Plant Protection, the Volcani Center, Bet Dagan, Israel. vinnie2@agri.gov.il"
Journal Title:		Biopolymers
Year:		2001
Volume:		60
Issue:		6
Page Number:		460 - 473
DOI:		10.1002/1097-0282(2001)60:6<460::AID-BIP10181>3.0.CO;2-Y
ISSN/ISBN:		0006-3525 (Print) 0006-3525 (Linking)
Abstract:		"The development of a new integrated approach to the generation of a novel type of insect neuropeptide (Np) antagonists and putative insect control agents based on backbone cyclic compounds is described. The approach, termed the backbone cyclic neuropeptide-based antagonist (BBC-NBA), was applied to the insect pyrokinin (PK)/pheromone biosynthesis activating neuropeptide (PBAN) family as a model, and led to the discovery of a potent linear lead antagonist and several highly potent, metabolically stable BBC antagonists, devoid of agonistic activity, which inhibited PBAN-mediated activities in moths in vivo. This review briefly summarizes our knowledge of insect Nps, describes the PK/PBAN Np family, presents the basic concepts behind the BBC-NBA approach, and introduces the advantages of this method for generation of Np agonists, antagonists and insecticide prototype molecules"
Keywords:		Amino Acid Sequence Animals Insect Hormones/antagonists & inhibitors/*chemistry Molecular Sequence Data Neuropeptides/antagonists & inhibitors/*chemistry Protein Conformation;
Notes:		"MedlineAltstein, M eng Research Support, Non-U.S. Gov't Review 2002/09/05 Biopolymers. 2001; 60(6):460-73. doi: 10.1002/1097-0282(2001)60:6<460::AID-BIP10181>3.0.CO; 2-Y"