« Previous Abstract"Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae"    Next AbstractImpact of biogas digesters on cookhouse volatile organic compound exposure for rural Kenyan farmwomen »

Annu Rev Physiol

Title:		G proteins and pheromone signaling
Author(s):		Dohlman HG;
Address:		"Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA. henrik_dohlman@med.unc.edu"
Journal Title:		Annu Rev Physiol
Year:		2002
Volume:		64
Issue:
Page Number:		129 - 152
DOI:		10.1146/annurev.physiol.64.081701.133448
ISSN/ISBN:		0066-4278 (Print) 0066-4278 (Linking)
Abstract:		"All cells have the capacity to respond to chemical and sensory stimuli. Central to many such signaling pathways is the heterotrimeric G protein, which transmits a signal from cell surface receptors to intracellular effectors. Recent studies using the yeast Saccharomyces cerevisiae have produced important advances in our understanding of G protein activation and inactivation. This review focuses on the mechanisms by which G proteins transmit a signal from peptide pheromone receptors to the mating response in yeast and how mechanisms elucidated in yeast can provide insights to signaling events in more complex organisms"
Keywords:		GTP-Binding Proteins/*physiology Pheromones/*physiology Saccharomyces cerevisiae/*physiology Signal Transduction/*physiology;
Notes:		"MedlineDohlman, Henrik G eng GM55316/GM/NIGMS NIH HHS/ GM59167/GM/NIGMS NIH HHS/ Research Support, U.S. Gov't, P.H.S. Review 2002/02/05 Annu Rev Physiol. 2002; 64:129-52. doi: 10.1146/annurev.physiol.64.081701.133448"