| Title: | Neuronal KGB-1 JNK MAPK signaling regulates the dauer developmental decision in response to environmental stress in Caenorhabditis elegans |
| Author(s): | Dogra D; Kulalert W; Schroeder FC; Kim DH; |
| Address: | "Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Boyce Thompson Institute, Ithaca, NY 14853, USA. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA" |
| ISSN/ISBN: | 1943-2631 (Electronic) 0016-6731 (Print) 0016-6731 (Linking) |
| Abstract: | "In response to stressful growth conditions of high population density, food scarcity, and elevated temperature, young larvae of nematode Caenorhabditis elegans can enter a developmentally arrested stage called dauer that is characterized by dramatic anatomic and metabolic remodeling. Genetic analysis of dauer formation of C. elegans has served as an experimental paradigm for the identification and characterization of conserved neuroendocrine signaling pathways. Here, we report the identification and characterization of a conserved c-Jun N-terminal Kinase-like mitogen-activated protein kinase (MAPK) pathway that is required for dauer formation in response to environmental stressors. We observed that loss-of-function mutations in the MLK-1-MEK-1-KGB-1 MAPK pathway suppress dauer entry. A loss-of-function mutation in the VHP-1 MAPK phosphatase, a negative regulator of KGB-1 signaling, results in constitutive dauer formation, which is dependent on the presence of dauer pheromone but independent of diminished food levels or elevated temperatures. Our data suggest that the KGB-1 pathway acts in the sensory neurons, in parallel to established insulin and TGF-beta signaling pathways, to transduce the dauer-inducing environmental cues of diminished food levels and elevated temperature" |
| Keywords: | Animals *Caenorhabditis elegans Caenorhabditis elegans Jnk mapk KGB-1 pathway dauer decision sensory neurons; |
| Notes: | "MedlineDogra, Deepshikha Kulalert, Warakorn Schroeder, Frank C Kim, Dennis H eng P40 OD010440/OD/NIH HHS/ R01 GM084477/GM/NIGMS NIH HHS/ R35 GM131877/GM/NIGMS NIH HHS/ R35 GM141794/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural 2021/11/03 Genetics. 2022 Jan 4; 220(1):iyab186. doi: 10.1093/genetics/iyab186" |
