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Toxins (Basel)

Title:		Biocontrol Potential of Antagonistic Yeasts on In Vitro and In Vivo Aspergillus Growth and Its AFB(1) Production
Author(s):		Dikmetas DN; Ozer H; Karbancioglu-Guler F;
Address:		"Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Istanbul, Turkiye. The Scientific and Technological Research Council of Turkiye (TUBITAK), Marmara Research Center (MRC), 41470 Gebze, Turkiye"
Journal Title:		Toxins (Basel)
Year:		2023
Volume:		20230619
Issue:		6
Page Number:		-
DOI:		10.3390/toxins15060402
ISSN/ISBN:		2072-6651 (Electronic) 2072-6651 (Linking)
Abstract:		"Aspergillus flavus is a major aflatoxin B(1), posing significant health concerns to humans, crops, and producer fungi. Due to the undesirable consequences of the usage of synthetic fungicides, biological control using yeasts has gained more attention. In this study, eight isolates of epiphytic yeasts belonging to Moesziomyces sp., Meyerozyma sp. and Metschnikowia sp., which have been identified as antagonists, were isolated from different plants, including grapes, blueberries, hawthorns, hoskiran, beans and grape leaf. While volatile organic compounds (VOCs) produced by Moesziomyces bullatus DN-FY, Metschnikowia aff. pulcherrima DN-MP and Metschnikowia aff. pulcherrima 32-AMM reduced in vitro A. flavus mycelial growth and sporulation, only VOCs produced by Metschnikowia aff. fructicola 1-UDM were found to be effective at reducing in vitro AFB(1) production. All yeasts reduced the mycelial growth of A. flavus by 76-91%, while AFB(1) production reduced to 1.26-10.15 ng/g and the control plates' growth was 1773 ng/g. The most effective yeast, Metschnikowia aff. Pulcherrima DN-HS, reduced Aspergillus flavus growth and aflatoxin B(1) production on hazelnuts. The AFB(1) content on hazelnuts reduced to 333.01 ng/g from 536.74 ng/g. To our knowledge, this is the first report of yeasts isolated from plants being tested as potential biological control agents to reduce AFB(1) production on hazelnuts"
Keywords:		Humans Aflatoxin B1/toxicity Yeasts Aspergillus Fungi Aspergillus flavus *Metschnikowia *Vitis/microbiology Aspergillus spp.aflatoxin antagonistic yeast biocontrol hazelnut mycotoxin volatile organic compounds;
Notes:		"MedlineDikmetas, Dilara Nur Ozer, Hayrettin Karbancioglu-Guler, Funda eng Research Support, Non-U.S. Gov't Switzerland 2023/06/27 Toxins (Basel). 2023 Jun 19; 15(6):402. doi: 10.3390/toxins15060402"