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Regul Toxicol Pharmacol

Title:		Derivation and application of indoor air screening values for inhalation exposure to semi-volatile organic compounds
Author(s):		Deveau M; Wille SM;
Address:		"Water and Air Quality Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Ave. West, AL: 4903B, Ottawa, ON, K1A 0K9, Canada. Electronic address: michelle.deveau@hc-sc.gc.ca. Water and Air Quality Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Ave. West, AL: 4903B, Ottawa, ON, K1A 0K9, Canada"
Journal Title:		Regul Toxicol Pharmacol
Year:		2023
Volume:		20230727
Issue:
Page Number:		105463 -
DOI:		10.1016/j.yrtph.2023.105463
ISSN/ISBN:		1096-0295 (Electronic) 0273-2300 (Linking)
Abstract:		"Semi-volatile organic compounds (SVOCs) are being increasingly studied in indoor air. The absence of health-based inhalation exposure guidelines for most SVOCs impedes the interpretation of indoor air concentrations from a health risk context. To accelerate the derivation of screening values for a large number of SVOCs, a tiered framework was developed to evaluate and adjust published hazard assessments for SVOCs to calculate benchmarks relevant for evaluation of inhalation risk. Inhalation screening values were derived for 43 SVOCs considered in this study, most of which required extrapolation from oral exposure guidelines. The screening values were compared to published SVOC concentrations in homes in Canada to evaluate the potential health risks of chronic exposure to SVOCs in indoor residential environments. SVOCs that could be prioritized for further evaluation were dibutyl phthalates (DBP), di(2-ethylhexyl) phthalate (DEHP) and polybrominated diphenyl ethers (PBDEs). The framework could be applied more broadly in the future to derive screening values for other non-traditional indoor air contaminants with limited inhalation hazard data or assessments"
Keywords:		"*Volatile Organic Compounds/analysis Inhalation Exposure/analysis *Air Pollution, Indoor/analysis *Air Pollutants/analysis Dibutyl Phthalate/analysis Dbp Dehp Dose-response Indoor air Inhalation route Pbde Risk assessment Route-to-route extrapolation Scre;"
Notes:		"MedlineDeveau, Michelle Wille, Stephanie M eng Netherlands 2023/07/30 Regul Toxicol Pharmacol. 2023 Sep; 143:105463. doi: 10.1016/j.yrtph.2023.105463. Epub 2023 Jul 27"