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Biochem Biophys Res Commun

Title:		Replicative aging of the yeast does not require DNA replication
Author(s):		Zadrag R; Bartosz G; Bilinski T;
Address:		"Department of Biochemistry and Cell Biology, University of Rzeszow, Poland. zadrag@univ.rzezow.pl"
Journal Title:		Biochem Biophys Res Commun
Year:		2005
Volume:		333
Issue:		1
Page Number:		138 - 141
DOI:		10.1016/j.bbrc.2005.05.081
ISSN/ISBN:		0006-291X (Print) 0006-291X (Linking)
Abstract:		"Mating pheromone treatment resulting in shmoo formation is a physiologically relevant model for separation of cell growth and division processes in the yeast Saccharomyces cerevisiae. Using this attitude we demonstrate that yeast loses its capacity for division at a faster rate when engaged in intensive growth and metabolism without cell divisions (in the shmoo state) than during normal reproductive growth. These results suggest that limitation of the division potential in the yeast is not due to a counter of cell divisions but is of growth/metabolic nature, perhaps involving attaining a limitation of cell volume"
Keywords:		Aging/drug effects/*physiology Cell Division/drug effects/*physiology Cell Proliferation/drug effects Cellular Senescence/drug effects/*physiology DNA Replication Pheromones/*pharmacology Saccharomyces cerevisiae/cytology/drug effects/*genetics/*growth &;
Notes:		"MedlineZadrag, Renata Bartosz, Grzegorz Bilinski, Tomasz eng Research Support, Non-U.S. Gov't 2005/06/09 Biochem Biophys Res Commun. 2005 Jul 22; 333(1):138-41. doi: 10.1016/j.bbrc.2005.05.081"