| Title: | Quantitative investigation of vascular response to mesenteric venous thrombosis using large-field-of-view photoacoustic microscopy |
| Address: | "Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China" |
| ISSN/ISBN: | 1864-0648 (Electronic) 1864-063X (Linking) |
| Abstract: | "Mesenteric venous thrombosis (MVT) is one of major causes leading to severe mesenteric ischemia. Vascular network plays an important role during the occurrence and development of MVT. However, there lacks an appropriate imaging method, which features advanced volumetric resolving capability, superior sensitivity to hemoglobin, and ultra-large field-of-view (FOV), to investigate vascular response of MVT. In this study, we developed and applied a large-FOV optical resolution photoacoustic microscopy to quantify the vascular response during the entire course of two different MVT models in which we ligated the superior mesenteric vein and inferior mesenteric vein, respectively. Furthermore, we developed a quantitative algorithm to derive total vascular length, relative concentration of total hemoglobin and vascular density over the FOV to reveal different vascular responses in different MVT models" |
| Keywords: | "Animals Female Mesenteric Veins/*diagnostic imaging *Microscopy *Photoacoustic Techniques Rats Rats, Sprague-Dawley Thrombosis/*diagnostic imaging mesenteric venous thrombosis optical resolution photoacoustic microscopy urinary volatile organic compounds;" |
| Notes: | "MedlineQin, Wei Qi, Weizhi Xi, Lei eng start-up grant/Southern University of Science and Technology/International 61775028/National Natural Science Foundation of China/International 61528401/National Natural Science Foundation of China/International 81571722/National Natural Science Foundation of China/International Research Support, Non-U.S. Gov't Germany 2019/08/08 J Biophotonics. 2019 Dec; 12(12):e201900198. doi: 10.1002/jbio.201900198. Epub 2019 Aug 21" |
