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Science

Title:		Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
Author(s):		Prahlad V; Cornelius T; Morimoto RI;
Address:		"Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA"
Journal Title:		Science
Year:		2008
Volume:		320
Issue:		5877
Page Number:		811 - 814
DOI:		10.1126/science.1156093
ISSN/ISBN:		1095-9203 (Electronic) 0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change"
Keywords:		"Animals Caenorhabditis elegans/cytology/genetics/*physiology Caenorhabditis elegans Proteins/genetics/physiology Genes, Helminth Heat-Shock Proteins/genetics/physiology Heat-Shock Response/genetics/*physiology Models, Neurological Mutation Neurons, Affere;"
Notes:		"MedlinePrahlad, Veena Cornelius, Tyler Morimoto, Richard I eng R37 GM038109/GM/NIGMS NIH HHS/ R37 GM038109-19/GM/NIGMS NIH HHS/ R01 AG026647-02/AG/NIA NIH HHS/ R01 AG026647-03/AG/NIA NIH HHS/ R01 GM038109/GM/NIGMS NIH HHS/ R37 GM038109-22/GM/NIGMS NIH HHS/ R37 GM038109-20/GM/NIGMS NIH HHS/ R01 AG026647/AG/NIA NIH HHS/ R01 AG026647-01/AG/NIA NIH HHS/ R01 AG026647-04/AG/NIA NIH HHS/ R37 GM038109-21/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2008/05/10 Science. 2008 May 9; 320(5877):811-4. doi: 10.1126/science.1156093"