| Title: | An Update on the Use of Exhaled Breath Analysis for the Early Detection of Lung Cancer |
| Author(s): | Peled N; Fuchs V; Kestenbaum EH; Oscar E; Bitran R; |
| Address: | "Shaare Zedek Medical Center, The Hebrew University, Jerusalem, Israel. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center, Beer-Sheva, Israel" |
| ISSN/ISBN: | 1179-2728 (Print) 1179-2728 (Electronic) 1179-2728 (Linking) |
| Abstract: | "Lung cancer has historically been the main responsible for cancer associated deaths. Owing to this is our current inability to screen for and diagnose early pathological findings, preventing us from a timely intervention when cure is still achievable. Over the last decade, together with the extraordinary progress in therapeutical alternatives in the field, there has been an ongoing search for a biomarker that would allow for this. Numerous technologies have been developed but their clinical application is yet to come. In this review, we provide an update on volatile organic compounds, a non-invasive method that can hold the key for detecting early metabolic pathway changes in carcinogenesis. For its compilation, web-based search engines of scientific literature such as PubMed were explored and reviewed, using articles, research, and papers deemed meaningful by authors discretion. After a brief description, we depict how this technique can complement current methods and present the value of electronic noses in the identification of the 'breathprint'. Lastly, we bring some of the latest updates in the field together with the current limitations and final remarks" |
| Keywords: | E-nose Gc-ms Voc biomarkers electronic nose lung cancer volatile organic compounds; |
| Notes: | "PubMed-not-MEDLINEPeled, Nir Fuchs, Vered Kestenbaum, Emily H Oscar, Elron Bitran, Raul eng Review New Zealand 2021/08/26 Lung Cancer (Auckl). 2021 Aug 16; 12:81-92. doi: 10.2147/LCTT.S320493. eCollection 2021" |
