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Sci Total Environ

Title:		Regional assessment of ambient volatile organic compounds from biopharmaceutical R&D complex
Author(s):		Pan Y; Liu Q; Liu FF; Qian GR; Xu ZP;
Address:		"Department of Environmental Science and Engineering, Shanghai University, Shanghai, China"
Journal Title:		Sci Total Environ
Year:		2011
Volume:		20110809
Issue:		20
Page Number:		4289 - 4296
DOI:		10.1016/j.scitotenv.2011.07.014
ISSN/ISBN:		1879-1026 (Electronic) 0048-9697 (Linking)
Abstract:		"Biopharmaceutical R&D complexes are major emission sources of volatile organic compounds (VOCs), which may pose potential health risks for staff on site and residents nearby. In this paper health risk assessments were performed for the VOCs in the ambient air of a typical biopharmaceutical R&D complex in China. Results showed halogenated and alkyl compounds were dominant components among 24 major VOCs from 9 selected sampling sites, inside or around the complex. The principal component analysis (PCA) indicated VOCs were generated predominantly from the biopharmaceutical research activities (factor 1 (F1), 71.6%) and traffic vehicles (factor 2 (F2), 15.4%), which were confirmed by contour maps of five selected VOCs (benzene, toluene, chlorobenzene, methylene chloride and n-hexane) simulated by Golden Software Surfer. The cumulative cancer risks for the staff on site and residents nearby were investigated and results showed the risk value were 1.01E--5 and 2.03E--5, respectively, higher than the threshold value of 1.0E--6. These results indicated that elevated VOCs from biopharmaceutical R&D complex are potential risks to the public health. Furthermore, the human health risk assessment revealed that 1,2-dichloroethane, methylene chloride, carbon tetrachloride and benzene were the dominant risk contributors for staff on site, while methyl chloride, carbon tetrachloride, 1,2-dichloroethane and tetrahydrofuran for residents nearby. As a conclusion, this work suggests that proper control strategy should be taken for VOCs releasing to minimize the public health risks, especially for the halogenated compounds"
Keywords:		Air Pollutants/*analysis/toxicity *Biopharmaceutics/standards China *Drug Industry/standards *Environmental Monitoring/methods/statistics & numerical data Humans Neoplasms/chemically induced Principal Component Analysis Public Health Risk Assessment Volat;
Notes:		"MedlinePan, Y Liu, Q Liu, F F Qian, G R Xu, Z P eng Research Support, Non-U.S. Gov't Netherlands 2011/08/13 Sci Total Environ. 2011 Sep 15; 409(20):4289-96. doi: 10.1016/j.scitotenv.2011.07.014. Epub 2011 Aug 9"