Title: | Synthetic pheromones that promote inter-male aggression in mice |
Author(s): | Novotny M; Harvey S; Jemiolo B; Alberts J; |
ISSN/ISBN: | 0027-8424 (Print) 1091-6490 (Electronic) 0027-8424 (Linking) |
Abstract: | "Two volatile constituents of male mouse urine, dehydro-exo-brevicomin and 2-(sec-butyl)-dihydrothiazole, have been found active in bioassays of inter-male aggressive behavior. The two synthetic compounds act synergistically when added to castrated male urine but not when added to water, and they provoke fighting that is quantitatively and qualitatively comparable to that elicited by intact male urine" |
Keywords: | "Aggression/*drug effects Animals Biological Assay Castration Humans Male Mice Mice, Inbred C57BL Pheromones/*pharmacology/urine;" |
Notes: | "MedlineNovotny, M Harvey, S Jemiolo, B Alberts, J eng MH-00222/MH/NIMH NIH HHS/ R01 HD 14889/HD/NICHD NIH HHS/ Research Support, U.S. Gov't, P.H.S. 1985/04/01 Proc Natl Acad Sci U S A. 1985 Apr; 82(7):2059-61. doi: 10.1073/pnas.82.7.2059" |