| Title: | The Grueneberg olfactory organ neuroepithelium recovers after injury |
| Author(s): | Chehrehasa F; Jacques A; St John JA; Ekberg JAK; |
| Address: | "School of Biomedical Sciences, Queensland University of Technology, Box 2434, QLD 4001, Australia; Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery, Griffith University, 170 Kessels Rd, Nathan 4111, Australia. Electronic address: fatemeh.chehrehasa@qut.edu.au. School of Biomedical Sciences, Queensland University of Technology, Box 2434, QLD 4001, Australia. Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery, Griffith University, 170 Kessels Rd, Nathan 4111, Australia; Menzies Health Institute Queensland, Griffith University, University Drive, Southport 4222, QLD, Australia" |
| DOI: | 10.1016/j.brainres.2018.03.020 |
| ISSN/ISBN: | 1872-6240 (Electronic) 0006-8993 (Linking) |
| Abstract: | "The Grueneberg organ (also termed Grueneberg ganglion) is an olfactory subsystem at the rostral nasal septum of rodents, and has been suggested to exist also in humans. Grueneberg organ neurons respond to coldness and alarm pheromones, but the anatomical arrangement and regenerative capacity are not fully characterised. We examined the relationship between the glia and the neurons using crosses of two transgenic mouse lines, S100ss-DsRed and OMP-ZsGreen, to visualise olfactory ensheathing cells (OECs) and Grueneberg olfactory neurons, respectively. Within the epithelium, Grueneberg organ OECs were in direct contact with Grueneberg organ neuron cell bodies. Individual axons from the neurons initially grew over the surface of the OECs before forming larger fascicles consisting of numerous axons and OECs. Considering the location of the Grueneberg organ so close to the external environment, it may be that the Grueneberg neurons are likely to be subject to damage suggesting that as in other olfactory regions there is a capacity for recovery after injury. Here, we used a well characterised model of olfactory nervous system injury, unilateral bulbectomy, to determine whether Grueneberg organ neurons degenerate after injury. We found that Grueneberg organ neurons degenerated in response to the axotomy, yet by 11?ª+days post injury neurons and/or axons were detected again within the epithelium. Our results demonstrate that while Grueneberg organ neurons and glia have a distinct relationship in the epithelium, they have largely similar characteristics to that of the main olfactory neurons and glia" |
| Keywords: | "Animals Astrocytes/cytology/*physiology Axotomy Mice, Transgenic Neural Pathways/cytology/physiology Neuroepithelial Cells/cytology/*physiology Olfactory Bulb/cytology/*physiology Olfactory Receptor Neurons/cytology/*physiology *Regeneration Axon Degenera;" |
| Notes: | "MedlineChehrehasa, Fatemeh Jacques, Angela St John, James A Ekberg, Jenny A K eng Research Support, Non-U.S. Gov't Netherlands 2018/03/24 Brain Res. 2018 Jun 1; 1688:65-72. doi: 10.1016/j.brainres.2018.03.020. Epub 2018 Mar 20" |
