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Respir Physiol Neurobiol

Title:		Real time analysis of volatile organic compounds (VOCs) in centenarians
Author(s):		Mazzatenta A; Pokorski M; Di Giulio C;
Address:		"Physiology and Physiopathology Section, Department of Neuroscience, Imaging and Clinical Science, University of Chieti-Pescara 'G. d'Annunzio', Chieti, Italy. Electronic address: amazzatenta@yahoo.com. Public Higher Medical Professional School in Opole, Poland; Institute of Psychology, Opole University, Opole, Poland. Electronic address: m_pokorski@hotmail.com. Physiology and Physiopathology Section, Department of Neuroscience, Imaging and Clinical Science, University of Chieti-Pescara 'G. d'Annunzio', Chieti, Italy"
Journal Title:		Respir Physiol Neurobiol
Year:		2015
Volume:		20141224
Issue:
Page Number:		47 - 51
DOI:		10.1016/j.resp.2014.12.014
ISSN/ISBN:		1878-1519 (Electronic) 1569-9048 (Linking)
Abstract:		"Centenarians are a model to study human longevity and the physiological process of aging. A plethora of studies on this model show the complexity of the system. Laboratory studies fail to find a biomarker of senescence. The real time exhaled breath volatile organic compounds (VOCs) has been suggested as a new biomarker to detect and monitor physiological processes in the respiratory system. VOCs exhaled by centenarians have not been studied in the general population and across-age-groups. In the present study we investigated, in real time, the breath properties and VOC exhaled content in healthy centenarians as compared with non-centenarian seniors and young healthy subjects. We found distinctly different breath pattern and distribution profiles of VOCs in the centenarians. Thus, the VOCs measurement allowed to discriminate the differences between the age-groups. We propose a VOCs fingerprint as a biomarker underlying the physiological mechanisms of aging and longevity. Longevity should be considered physiologically as a new phase of life, characteristic of the well adapted subject"
Keywords:		"Adult Aged, 80 and over Breath Tests/methods Humans *Longevity/physiology *Respiration Time Factors Volatile Organic Compounds/*analysis Young Adult Aging Centenarian Real time breath VOC fingerprint VOC profile Volatile organic compound;Neuroscience;"
Notes:		"MedlineMazzatenta, Andrea Pokorski, Mieczyslaw Di Giulio, Camillo eng Observational Study Netherlands 2014/12/30 Respir Physiol Neurobiol. 2015 Apr; 209:47-51. doi: 10.1016/j.resp.2014.12.014. Epub 2014 Dec 24"