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Environ Mol Mutagen

Title:		Oxidative stress index is increased in children exposed to industrial discharges and is inversely correlated with metabolite excretion of voc
Author(s):		Lopez-Vargas R; Mendez-Serrano A; Albores-Medina A; Oropeza-Hernandez F; Hernandez-Cadena L; Mercado-Calderon F; Alvarado-Toledo E; Herrera-Morales S; Arellano-Aguilar O; Garcia-Vargas G; Montero-Montoya R;
Address:		"Departamento de Toxicologia Ambiental, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, CDMX, Mexico. Centro Fray Julian Garces, Derechos Humanos y Desarrollo Comunitario, A. C. Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados CDMX, Mexico. Laboratorio de Toxicologia Industrial, Hospital General de Nanchital, Petroleos Mexicanos, Mexico. Instituto Nacional de Salud Publica, Ciudad de Mexico, Mexico. Coordinacion de Salud en el Trabajo, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico. Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico"
Journal Title:		Environ Mol Mutagen
Year:		2018
Volume:		20180703
Issue:		7
Page Number:		639 - 652
DOI:		10.1002/em.22207
ISSN/ISBN:		1098-2280 (Electronic) 0893-6692 (Linking)
Abstract:		"Although the Atoyac River has been classified as highly polluted by environmental authorities, several communities are settled on its banks, affecting around 1.5 million persons, as well as farmland, due to an environmental distribution of toxics in the area. Our aim was to demonstrate that this environment affects important physiological processes that have an impact in health, so we conducted a study of schoolchildren from small communities on the banks of the river and in another similar town located far from it. 91 and 93 students, boys and girls, were studied from each site for oxidative stress index (OSI), calculated from the total antioxidant capacity and the total oxidative status, BTEX metabolite excretion and relevant metabolic polymorphisms participating in the bioactivation-detoxification of most VOC: CYP2E1 RsaI, NQO1 C609T, and null polymorphisms of GSTT1 and GSTM1. Results showed that OSI was significantly higher in children living by the river (5.23 +/- 3.4 vs 2.59 +/- 1.46, 95% C.I.). At this site, OSI was correlated with diminished metabolite excretion and a diminished antioxidant capacity; an association with genotypes CYP2E1RsaI (c2c2), GSTT1 present and NQO1*2 (CC) was also observed. Furthermore, boys at this site exhibited a diminished BMI compared to boys from the other community who were younger. IN CONCLUSION: children living at polluted sites like this, show early biological effects that might lead to health problems in their adult life. Environmental protection should be enforced to protect people's health in these sites where not even environmental monitoring is done. Environ. Mol. Mutagen. 59:639-652, 2018. (c) 2018 Wiley Periodicals, Inc"
Keywords:		"Adolescent Child Environmental Exposure/*adverse effects Female Genotype Glutathione Transferase/genetics/metabolism Humans Inactivation, Metabolic Industrial Waste/*adverse effects/analysis Male Mexico Oxidative Stress/*drug effects Polymorphism, Genetic;"
Notes:		"MedlineLopez-Vargas, Rocio Mendez-Serrano, Alejandra Albores-Medina, Arnulfo Oropeza-Hernandez, Fernando Hernandez-Cadena, Leticia Mercado-Calderon, Franciso Alvarado-Toledo, Esmeralda Herrera-Morales, Selene Arellano-Aguilar, Omar Garcia-Vargas, Guadalupe Montero-Montoya, Regina eng Research Support, Non-U.S. Gov't 2018/07/04 Environ Mol Mutagen. 2018 Aug; 59(7):639-652. doi: 10.1002/em.22207. Epub 2018 Jul 3"