| Title: | Rapid Diagnosis of Tuberculosis from Analysis of Urine Volatile Organic Compounds |
| Author(s): | Lim SH; Martino R; Anikst V; Xu Z; Mix S; Benjamin R; Schub H; Eiden M; Rhodes PA; Banaei N; |
| Address: | "Metabolomx, Mountain View, California 94043, USA. Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA. Alameda County Medical Center, Oakland, California 94602, USA. Clinical Microbiology Laboratory, Stanford University Medical Center, Palo Alto, California 94304, USA" |
| DOI: | 10.1021/acssensors.6b00309 |
| ISSN/ISBN: | 2379-3694 (Electronic) 2379-3694 (Linking) |
| Abstract: | "The World Health Organization has called for simple, sensitive, and non-sputum diagnostics for tuberculosis. We report development of a urine tuberculosis test using a colorimetric sensor array (CSA). The sensor comprised of 73 different indicators captures high-dimensional, spatiotemporal signatures of volatile chemicals emitted by human urine samples. The sensor responses to 63 urine samples collected from 22 tuberculosis cases and 41 symptomatic controls were measured under five different urine test conditions. Basified testing condition yielded the best accuracy with 85.5% sensitivity and 79.5% specificity. The CSA urine assay offers desired features needed for tuberculosis diagnosis in endemic settings" |
| Keywords: | Adult Aged Case-Control Studies Colorimetry/*methods/standards Endemic Diseases Female Humans Male Middle Aged Sensitivity and Specificity Tuberculosis/*diagnosis Volatile Organic Compounds/*urine Young Adult chemical sensor colorimetric sensor array elec; |
| Notes: | "MedlineLim, Sung H Martino, Raymond Anikst, Victoria Xu, Zeyu Mix, Samantha Benjamin, Robert Schub, Herbert Eiden, Michael Rhodes, Paul A Banaei, Niaz eng UL1 TR001085/TR/NCATS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2016/07/22 ACS Sens. 2016 Jul 22; 1(7):852-856. doi: 10.1021/acssensors.6b00309. Epub 2016 Jun 9" |
