| Title: | Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinase |
| Address: | "Department of Biology and Volen Center for Complex Systems, Brandeis University, MS 008, 415 South Street, Waltham, MA 02454, USA" |
| DOI: | 10.1016/s0896-6273(02)00572-x |
| ISSN/ISBN: | 0896-6273 (Print) 0896-6273 (Linking) |
| Abstract: | "Sensory signals regulate multiple developmental and behavioral circuits in C. elegans, providing a genetically tractable system in which to investigate the mechanisms underlying the acquisition and integration of sensory information. kin-29 mutants are defective in the expression of a set of chemoreceptor genes, and exhibit characteristics associated with altered sensory signaling, including increased lifespan, decreased body size, and deregulated entry into the dauer developmental stage. kin-29 encodes a Ser/Thr kinase with similarity to the MARK and AMPK/SNF1 family of kinases. We show that KIN-29 acts cell-autonomously and non-cell-autonomously in sensory neurons to regulate chemoreceptor expression, body size, and the dauer decision, suggesting that kin-29 function is essential for the correct acquisition and transduction of sensory information" |
| Keywords: | "Active Transport, Cell Nucleus/physiology Amino Acid Sequence Animals Animals, Genetically Modified Caenorhabditis elegans/*physiology Caenorhabditis elegans Proteins Chemoreceptor Cells/*physiology Cloning, Molecular *Gene Expression Regulation Genes, Re;" |
| Notes: | "MedlineLanjuin, Anne Sengupta, Piali eng 2002/02/08 Neuron. 2002 Jan 31; 33(3):369-81. doi: 10.1016/s0896-6273(02)00572-x" |
