« Previous AbstractTyramine: from octopamine precursor to neuroactive chemical in insects    Next AbstractQuantitative detection of benzene in toluene- and xylene-rich atmospheres using high-kinetic-energy ion mobility spectrometry (IMS) »

Angew Chem Int Ed Engl

Title:		Volatile Organic Compound Based Probe for Induced Volatolomics of Cancers
Author(s):		Lange J; Eddhif B; Tarighi M; Garandeau T; Peraudeau E; Clarhaut J; Renoux B; Papot S; Poinot P;
Address:		"University of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Materiaux de Poitiers (IC2MP), E.BiCoM Team, 4 rue Michel-Brunet, TSA 51106, 86073, Poitiers cedex 9, France. University of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Materiaux de Poitiers (IC2MP), Groupe 'Systemes Moleculaires Programmes', rue Michel-Brunet, TSA 51106, 86073, Poitiers cedex 9, France. CHU de Poitiers, 86021, Poitiers, France. Seekyo SA, 4 rue Carol Heitz, 86000, Poitiers, France"
Journal Title:		Angew Chem Int Ed Engl
Year:		2019
Volume:		20191022
Issue:		49
Page Number:		17563 - 17566
DOI:		10.1002/anie.201906261
ISSN/ISBN:		1521-3773 (Electronic) 1433-7851 (Linking)
Abstract:		"The development of efficient protocols for cancer diagnosis remains highly challenging. An emerging approach relies on the detection in exhaled breath of volatile organic compounds (VOC) produced by tumours. In this context, described here is a novel strategy in which a VOC-based probe is converted selectively in malignant tissues, by a tumour-associated enzyme, for releasing the corresponding VOC. The latter is then detected in the exhaled breath as a tumour marker for cancer diagnosis. This approach allows the detection of several different tumours in mice, the monitoring of tumour growth and tumour response to chemotherapy. Thus, the concept of 'induced volatolomics' provides a new way to explore biological processes using VOC-based probes that could be adapted to many biomedical applications"
Keywords:		"Animals Biomarkers, Tumor/*analysis/metabolism Biosensing Techniques Breath Tests Ethanol/*analysis/metabolism Exhalation Glucuronidase/metabolism Humans Hydrophobic and Hydrophilic Interactions Mice Mice, Nude Neoplasm Staging Neoplasms/*diagnosis Tumor;"
Notes:		"MedlineLange, Justin Eddhif, Balkis Tarighi, Mehrad Garandeau, Thea Peraudeau, Elodie Clarhaut, Jonathan Renoux, Brigitte Papot, Sebastien Poinot, Pauline eng Research Support, Non-U.S. Gov't Germany 2019/09/14 Angew Chem Int Ed Engl. 2019 Dec 2; 58(49):17563-17566. doi: 10.1002/anie.201906261. Epub 2019 Oct 22"